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Acute modulation of calcium currents and synaptic transmission by gabapentinoids
(Landes Bioscience, 2010-12)
Gabapentin and pregabalin are anticonvulsant drugs that are extensively used for the treatment of several neurological and psychiatric disorders. Gabapentinoids (GBPs) are known to have a high affinity binding to α2 δ-1 ...
3-Methylcrotonyl Coenzyme A (CoA) carboxylase complex is involved in the Xanthomonas citri subsp. Citri lifestyle during citrus infection
(Public Library of Science, 2018-06)
Citrus canker is a disease caused by the phytopathogen Xanthomonas citri subsp. citri (Xcc), bacterium which is unable to survive out of the host for extended periods of time. Once established inside the plant, the pathogen ...
Observations on Texas hypoxylons, including two new Hypoxylon species and widespread environmental isolates of the H. croceum complex identified by a polyphasic approach
(Taylor & Francis, 2019-08-28)
Two new species and a new combination of Hypoxylon from Texas were identified and described based on morphological, multigene phylogenetic (ITS [nuc rDNA internal transcribed spacer region ITS1-5.8S-ITS2], 28S [5′ 1200 bp ...
A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors
(Wiley Blackwell Publishing, Inc, 2021-04)
The α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug ...
Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection
(Biomedical Research Press Ltd, 2014-05)
This study examined the immunogenic properties of the fusion protein fimbria 2 ofBordetella pertussis(Fim2)—cholera toxin Bsubunit (CTB) in the intranasal murine model of infection. To this endB. pertussisFim2 coding ...
Allosteric modulation of retinal GABA receptors by ascorbic acid
(Society for Neuroscience, 2011-04)
Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells. ...
First record of the red alga Compsopogon caeruleus (Balbis ex C. Agardh) Montagne 1846 in the High Paraná River, Argentina-Paraguay
(Regional Euro-Asian Biological Invasions Centre, 2019-11)
The presence of a freshwater red alga (Rhodophyta), Compsopogon caeruleus, was recorded for the first time in the High Paraná River. It was detected in 2016 and 2017 at five points along 290 km of the border between Argentina ...
Correlation between functional and ultrastructural substrate in Brugada syndrome
(Elsevier, 2016-05)
Brugada syndrome (BS) was reported for the first time in 1992 and is associated with an ST-segment elevation in the right precordial leads in the absence of any demonstrable structural heart disease, as well as with sudden ...
The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin
(Elsevier, 2013-07)
The N-terminal stretch of human frataxin (hFXN) intermediate (residues 42?80) is not conserved throughout evolution and, under defined experimental conditions, behaves as a random-coil. Overexpression of hFXN56?210 in E. ...
Taxonomy and phylogeny of macrolepiota: Two new species from Brazil
(Taylor & Francis, 2018-09-24)
Macrolepiota is a poorly known genus in the Neotropics. In order to increase knowledge about this group, we collected specimens from the Atlantic Forest in southern and northeastern Brazil. Macrolepiota cyanolamellata and ...