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Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel
(ROCKEFELLER UNIV PRESS, 2006-02)
High conductance, calcium- and voltage-activated potassium (BK, MaxiK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory ...
Determination of the stoichiometry between alpha- and gamma 1 subunits of the BK channel using LRET
(Cell Press, 2018)
Two families of accessory proteins, beta and gamma, modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the gamma 1 subunit promotes a large shift of the BK conductance-voltage curve to ...
Modulation of BK channel voltage gating by different auxiliary β subunits
(2012)
Calcium- and voltage-activated potassium channels (BK) are regulated by a multiplicity of signals. The prevailing view is that different BK gating mechanisms converge to determine channel opening and that these gating ...
L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes
(Taylor and Francis Inc., 2011)
Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the ...
3 SUBTYPES OF ALPHA-BUNGAROTOXIN SENSITIVE NICOTINIC ACETYLCHOLINE-RECEPTORS ARE EXPRESSED IN CHICK RETINA
(Soc Neuroscience, 1993-02-01)
A recent report described the isolation of cDNA clones encoding alpha7 and alpha8 subunits of alpha-bungarotoxin-sensitive nicotinic ACh receptors (alphaBgtAChRs) from chick brain and demonstrated that they were related ...
Characterization of the regulatory subunit of Yarrowia lipolytica cAMP-dependent protein kinase. Evidences of a monomeric protein
(Elsevier Science Inc, 2011-05)
cAMP-dependent protein kinase (PKA) catalytic (C) and regulatory (R) subunits from Yarrowia lipolytica are encoded by single genes, TPK1 and RKA1, respectively. Here we performed the heterologous expression, purification ...
Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function
(American Society for Pharmacology and Experimental Therapeutics, 2017-03)
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding ...