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Activation of Hes1 and Msx1 in transgenic mouse embryonic stem cells increases differentiation into neural crest derivatives
(MDPI, 2018-12)
The neural crest (NC) comprises an ectodermal multipotent cell population that produces peripheral neurons, cartilage and smooth muscle cells, among other phenotypes. The participation of Hes1 and Msx1 when expressed in ...
A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells
(Cognizant Communication Corp, 2008-12)
Mouse embiyonic stem (ES) cells have the potential to differentiate into insulin-producing cells, but efficient protocols for in vitro differentiation have not been established. Here we have developed a new optimized ...
Stemformatics: Visualisation and sharing of stem cell gene expression
(Elsevier Science, 2013-05)
Genome-scale technologies are increasingly adopted by the stem cell research community, because of the potential to uncover the molecular events most informative about a stem cell state. These technologies also present ...
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells†
(Society for the Study of Reproduction, 2021-04)
The WNT signaling system plays an important but paradoxical role in the regulation of pluripotency. In the cow, IWR-1, which inhibits canonical WNT activation and has WNT-independentactions, promotes the derivation of ...
Acquisition of stem associated-features on metastatic osteosarcoma cells and their functional effects on mesenchymal stem cells
(Elsevier Science, 2020-04)
Background: Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly children and young adults. Metastases are a major clinical challenge in OS. In this context, 20% of OS patients are diagnosed ...
The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem-like Properties in Glioblastoma That Contribute to Tumorigenesis.
(American Association for Cancer Research, 2016-09)
KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness ...
Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
(Elsevier Ireland, 2017-04)
The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem ...
From Pituitary Stem Cell Differentiation to Regenerative Medicine
(Frontiers Media, 2021-01)
The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise during ...