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The prodrug approach: A successful tool for improving drug solubility
(2016-01-01)
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their ...
Rapid Determination of Water-Soluble and Fat-Soluble Vitamins in Commercial Formulations by MEEKC
(SPRINGER HEIDELBERG, 2010)
Microemulsion electrokinetic capillary chromatography has been successfully applied to the separation and determination of water-soluble vitamins (thiamine hydrochloride, riboflavin, niacin, pyridoxine hydrochloride, folic ...
Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended hildebrand solubility approach
(Universidad Nacional de Colombia, 2012)
The Extended Hildebrand Solubility Approach(EHSA) was applied in the presentwork to evaluate the solubility of theanalgesic drug acetaminophen (paracetamol)in polyethylene glycol 400 + watermixtures at 298.15 K. An ...
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility
(2016-03-01)
Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(2010-01-01)
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Solubility of argon and nitrogen in aqueous solutions of tetran- butylammonium bromide (TBAB) from 283.15 to 298.15 K and 101.325 kPa partial pressure of gas
This paper reports the solubility of argon and nitrogen in aqueous solutions of tetra-n-butylammonium
bromide (TBAB) in a concentration interval ranging from 0.2 to 1.0 mol kg 1 and temperatures between
283.15 K and ...
Solubility and solubility modeling of polycyclic aromatic hydrocarbons in subcritical water
(2013)
A static analytical equilibrium method was used to measure the binary and ternary solubilities of anthracene and p-terphenyl in subcritical water between 393 and 473 K and at 50 and 150 bar. Temperature was found to have ...
Solubility parameters, hydrophile-lipophile balance, and solubility in sucrose derivative surfactants obtained by GLC
(Asociación Química Argentina, 2002-11)
Specific retention volumes of different solvents were measured on coIumns containing two sucrose derivatives esters as stationary phase.Henry's constants were calculated and the solubility in the surfacnnts was obtaíned. ...
Solubility, porosity and fluid uptake of calcium silicate-based cements
(Univ Sao Paulo Fac Odontologia Bauru, 2018-01-01)
Objective: To evaluate the absorption/fluid uptake, solubility and porosity of White mineral trioxide aggregate (MTA) Angelus, Biodentine (BIO), and zinc oxide-eugenol (ZOE). Material and Methods: Solubility was evaluated ...