Now showing items 41-50 of 1824
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom
In Colombia, nearly 2.8% of the 4200 snakebite accidents recorded annually are inflicted by coral snakes (genus Micrurus). Micrurus dumerilii has a broad distribution in this country, especially in densely populated ...
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice
The effect of several drugs on the edema-forming activity of Bothrops asper venom was studied plethysmographically using the mouse foot pad assay. Bothrops asper venom induced a dose-dependent edema which developed rapidly ...
Phospholipase A2 myotoxins from Bothrops snake venoms
The genus Bothrops is distributed over all Latin America, From Mexico to Argentina, and comprises nearly 31 species of snake. In most of these countries, Bothrops spp. cause the majority of snake bit envenomations, which ...
Venomics Profiling of Thamnodynastes strigatus Unveils Matrix Metalloproteinases and Other Novel Proteins Recruited to the Toxin Arsenal of Rear-Fanged Snakes
(AMER CHEMICAL SOCWASHINGTON, 2012)
Rear-fanged and aglyphous snakes are usually considered not dangerous to humans because of their limited capacity of injecting venom. Therefore, only a few studies have been dedicated to characterizing the venom of the ...
Medicinal plants with inhibitory properties against snake venoms
Envenomations due to snake bites are commonly treated by parenteral administration of horse or sheep-derived polyclonal antivenoms aimed at the neutralization of toxins. However, despite the widespread success of this ...
Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
Rear-fanged snake venoms: an untapped source of novel compounds and potential drug leads
Animal venoms represent a diverse source of potentially valuable therapeutic compounds due to the high specificity and the potent biological activity of many toxins. Snake venom toxins, particularly disintegrins and proteases ...
Snake Venomic of Crotalus durissus terrificus-Correlation with Pharmacological Activities
(Amer Chemical Soc, 2014)
The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron microscopic study
The acute tissue damaging effects of Bothrops riper snake venom and a myotoxic Lys-49 phospholipase A2 (myotoxin In on the mouse cremaster muscle were studied by intravital and electron microscopy. Both venom and myotoxin ...
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...