Buscar
Mostrando ítems 611-620 de 1392
Wnt signaling modulates pre-and postsynaptic maturation: therapeutic considerations
(2010)
Wnt signaling regulates a wealth of aspects of nervous system development and function in embryonic stages and in adulthood. The expression of Wnt ligands and components of the Wnt signaling machinery in early stages of ...
beta-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure
(2010)
Alzheimer disease is a progressive neurodegenerative brain disorder that leads to major debilitating cognitive deficits. It is believed that the alterations capable of causing brain circuitry dysfunctions have a slow onset ...
The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Drosophila Fragile X Syndrome and hereditary spastic paraplegias
(2016)
The capacity of the nervous system to generate neuronal networks relies on the establishment and maintenance of synaptic contacts. Synapses are composed of functionally different presynaptic and postsynaptic compartments. ...
Synchronization of stochastic mean field networks of Hodgkin-Huxley neurons with noisy channels
(2019)
In this work we are interested in a mathematical model of the collective behavior of a fully connected network of finitely many neurons, when their number and when time go to infinity. We assume that every neuron follows ...
ALS-linked protein disulfide isomerase variants cause motor dysfunction
(2016)
Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
ALS-linked protein disulfide isomerase variants cause motor dysfunction
(2016)
Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
The neuromuscular junction of Xenopus tadpoles: Revisiting a classical model of early synaptogenesis and regeneration
(2018)
The frog neuromuscular junction (NMJ) has been extensively used as a model system to dissect the mechanisms involved in synapse formation, maturation, maintenance, regeneration, and function. Early NMJ synaptogenesis relies ...
Wnt - 7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons
(2008)
Wnt signaling is essential for neuronal development and the maintenance of the developing nervous system. Recent studies indicated that Wnt signaling modulates long term potentiation in adult hippocampal slices. We report ...
Generalidades De Los Neurotransmisores
(Facultad de PsicologíaPsicologíaColombia, 2009-12-30)
The neurotransmitter begins to act by releasing itself at the extremity of a neuron, while the propagation of the nervous flux develops, focusing on the precise points of the membrane of the next neuron. Neurotransmitters ...
A neural-network interpretation of selection in learning and behavior
(2001)
In their account of learning and behavior, the authors define an interactor as emitted behavior that operates on the environment, which excludes Pavlovian learning. A unified neural-network account of the operant-Pavlovian ...