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Now showing items 11-20 of 45
Molecular basis for the ph dependent structural transition of nitrophorin 4
(American Chemical Society, 2009-02)
Allostery can be defined in a broad sense as a structural change in a protein. The theoretical framework for allostery includes several formulations. In the stereochemical view, the activation event causes a local ...
Efficient synthesis of chiral Δ2-1,3,4-thiadiazolines from α-pinene and verbenone
(Pergamon-Elsevier Science Ltd, 2011-10)
The synthesis of chiral cyclobutane 1,3,4-thiadiazoline derivatives starting from (-)alfa pinene and (-)verbenone was studied. The diastereoisomeric excesses of the products obtained depended strongly upon the starting ...
Preparation and physicochemical characterization of drug loaded in castor oil-based polyurethane
(Springer, 2020-02-01)
Castor oil is an environmentally friendly alternative to hydrocarbon-based feedstocks for the synthesis of polyurethanes due to its major constituent, ricinoleic acid. This work aimed to obtain and characterize castor ...
Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning
(Aves, 2016)
Objective: The molecular mechanism of citrullination involves the calcium-dependent peptidylarginine deiminase (PAD) family of
enzymes. These enzymes induce a stereochemical modification of normal proteins and transform ...
NMR spin-spin couplings involving nuclei in the neighborhood of a carbonyl group. 3JCH couplings in α-substituted acetamides
(John Wiley & Sons Ltd, 2008-03)
In this work 3JCH spin-spin coupling constants (SSCCs) for the cis- and trans-conformers for α-X-acetamides (X = F, Cl, Br and CN) (1-4) were studied in detail since they were found to be notably different for both conformers. ...
Chiral auxiliary-mediated enantioenrichment of (±)-ibuprofen, under steglich conditions, with secondary alcohols derived from (R)-carvone
(Sociedade Brasileira de Química, 2010-03)
The synthesis of a series of chiral secondary alcohols derived from (R)-carvone, and the stereochemical outcome of their reaction with (±)-ibuprofen, is reported. The racemic drug was transformed into the corresponding ...
4-(2-Hydroxyphenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine and the 2-(2,3-dimethoxyphenyl)-, 2-(3,4-dimethoxyphenyl)- and 2-(2,5-dimethoxyphenyl)-substituted derivatives
(BLACKWELL PUBLISHING, 2007-07)
The 1,5-benzodiazepine ring system exhibits a puckered boatlike conformation for all four title compounds [4-(2-hydroxyphenyl)2- phenyl-2,3-dihydro-1H-1,5-benzodiazepine, C21H18N2O, (I), 2-(2,3-dimethoxyphenyl)-4-(2-hydr ...
Achieving Regio- And Stereo-control In The Fluorination Of Aziridines Under Acidic Conditions
(Royal Soc ChemistryCambridge, 2016)
ELECTRONIC INTERACTIONS IMPLIED BY THE NONADDITIVITY OF C-13 SUBSTITUENT PARAMETERS IN 2-SUBSTITUTED CYCLOHEXANONES
(John Wiley & Sons LtdW SussexInglaterra, 1994)