Now showing items 21-30 of 15875
Client-side selection of replicated web services: An empirical assessment
(Elsevier Science IncNew YorkEUA, 2008)
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
(Oxford Univ Press, 2018-04-06)
Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in ...
Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4
Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the virus genotype. Acridones, a group of compounds extracted from natural ...
Structure, function and evolution of the animal mitochondrial replicative DNA helicase
(Taylor & Francis Ltd, 2016-01-02)
The mitochondrial replicative DNA helicase is essential for animal mitochondrial DNA (mtDNA) maintenance. Deleterious mutations in the gene that encodes it cause mitochondrial dysfunction manifested in developmental delays, ...
The fork and the kinase: A DNA replication tale from a CHK1 perspective
(Elsevier Science, 2015-01)
Replication fork progression is being continuously hampered by exogenously introduced and naturally occurring DNA lesions and other physical obstacles. Checkpoint kinase 1 (Chk1) is activated at replication forks that ...
A model for analysing data portal performance: The biodiversity case
Currently, many museums, botanic gardens and herbariums keep data of biological collections and using computational tools researchers digitalize and provide access to their data using data portals. The replication of ...
Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication
(American Society For Microbiology, 2015-03)
The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified ...
The native speaker and nonnative speaker debate: what are the issues and what are the outcomes?
(Editora UnisinosSao LeopoldoBrasil, 2013)
Antimycobacterial activity of pyrazinoate prodrugs in replicating and non-replicating Mycobacterium tuberculosis
(Churchill Livingstone, 2016-07-01)
Tuberculosis (TB) is an important infectious disease caused by Mycobacterium tuberculosis (Mtb) and responsible for thousands of deaths every year. Although there are antimycobacterial drugs available in therapeutics, just ...
Bleomycin-induced γH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei
(Kluwer Academic Publishers, 2014)
© 2014, Springer Science+Business Media Dordrecht.Exposure to DNA damaging agents triggers phosphorylation of histone variant H2AX (generating γH2AX) in large chromatin regions flanking DNA lesions, allowing their ...