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Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior
(2017)
The prelimbic area (PL) of the medial Prefrontal cortex (mPFC) is involved in the acquisition and expression of conditioned and innate fear. Both types of fear share several neuronal pathways. It has been documented that ...
Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression
(2018)
Sigma sigma(1) and sigma(2) receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, ...
CRF binding protein facilitates the presence of CRF type 2 alpha receptor on the cell surface
(2016)
Corticotropin releasing factor binding protein (CRF-BP) was originally recognized as CRF sequestering protein. However, its differential subcellular localization in different brain nuclei suggests that CRF-BP may have ...
The influence of temperament and sex on inhibitory control games: predictive and non-predictive rewards
(2021)
The general aim of this thesis is to evaluate the behavioural and neurophysiological influence of Predictive and Non-predictive Reward strategies offered in a game, Temperament and Sex, on Inhibitory Control in children ...
Glutathione depletion induces spermatogonial cell autophagy
(2015)
The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important role in the antioxidant defenses of the spermatogenic epithelium. Autophagy ...
Transcriptome immunomodulation of in-feed additives in Atlantic salmon Salmo salar infested with sea lice Caligus rogercresseyi
(2015)
One of the most significant threats to the Chilean salmon aquaculture industry is the ectoparasitic sea louse caligus rogercresseyi. To cope with sea lice infestations, functional diets have become an important component ...
Insulin/adenosine axis linked signalling
(2017)
Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. ...
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
(2016)
The neurotransmitter GABA has been recently identified as a potent immunosuppressive agent that targets both innate and adaptive immune systems and prevents disease progression of several autoimmunity models. Mesenchymal ...
The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines
(2018)
It has been reported that one of the factors that promotes tumoral progression is the abnormal activation of the epithelial-mesenchymal transition program. This process is associated with tumoral cells acquiring invasive ...
Effects on Hedonic Feeding, Energy Expenditure and Balance of the Non-opioid Peptide DYN-A(2-17)
(2018)
The dynorphin (DYN) peptide family includes opioid and non-opioid peptides, yet the physiological role of the non-opioid DYN peptides remains poorly understood. Recent evidence shows that administering the non-opioid peptide ...