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Neuroprotective activity of a new erythropoietin formulation with increased penetration in the central nervous system
(Biomed central, 2011-11)
Apart from its hematopoietic effect, erythropoietin (EPO) is a molecule with high neuroprotective potential. However, its prolonged application may cause serious adverse effects due to the erythropoiesis stimulation. ...
Death switch for gene therapy: application to erythropoietin transgene expression
(Assoc Bras Divulg CientificaSao PauloBrasil, 2010)
Estudo da interação entre alumínio e os constituintes de formulações de eritropoetina empregando HPLC e AAS
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2009-03-05)
Erythropoietin (EPO) is a glycoprotein which stimulates the erythropoiesis (production of hemaceas) and is clinically used for the treatment of renal anemia. EPO formulations present usually elevated contamination by ...
Neuroprotective effects evaluation of a recombinant human low-glycosylation erythropoietin isoform.
(Universidad de Concepción.Facultad de Ciencias BiológicasDepartamento de Biología Celular y Molecular., 2018)
Erythropoietin (Epo) is a glycoprotein hormone that mainly regulates hematopoiesis, has a molecular weight of approximately 34 KDa and is made up of 165 amino acids, it has potential N- and Oglycosylation sites at residues ...
Activity increase in EpoR and Epo expression by intranasal recombinant human erythropoietin (rhEpo) administration in ischemic hippocampi of adult rats
(2014)
Erythropoietin in the nervous system is a potential neuroprotective factor for cerebral ischemic damage due to specific-binding to the erythropoietin receptor, which is associated with survival mechanisms. However, the ...
Activity increase in EpoR and Epo expression by intranasal recombinant human erythropoietin (rhEpo) administration in ischemic hippocampi of adult rats
(2014)
Erythropoietin in the nervous system is a potential neuroprotective factor for cerebral ischemic damage due to specific-binding to the erythropoietin receptor, which is associated with survival mechanisms. However, the ...
Strategy for erythroid differentiation in ex vivo cultures: Lentiviral genetic modification of human hematopoietic stem cells with erythropoietin gene
(Soc Bioscience Bioengineering Japan, 2017-11)
If cultured in appropriate conditions, such as supplementing culture media with costly cytokines and growth factors, hematopoietic stem/progenitor cells (HSPCs) from different origins have shown to be an adequate source ...