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GFP transient expression and silencing in fragaria x ananassa
(IOS Press, 2020-01)
Background: Stable transformation, transient expression, and post-transcriptional gene silencing (PTGS) are powerful methodologies that allow exploration of gene function. Objective: We aimed to apply these methodologies ...
Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats
(Hindawi Publishing Corporation, 2019-10)
From studies on different species and in cell culture systems, it has been suggested that vitamin D metabolites might affect themetabolism and elimination of xenobiotics. Although most studies performed on rodents and cell ...
Tumor Necrosis Factor-Mediated Survival of CD169 + Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection
(American Society for Microbiology, 2018-02)
Innate immune activation is essential to mount an effective antiviral response and to prime adaptive immunity. Although a crucial role of CD169+ cells during vesicular stomatitis virus (VSV) infections is increasingly ...
Role of CaMKII in post acidosis arrhythmias: A simulation study using a human myocyte model
(Academic Press Ltd - Elsevier Science Ltd, 2013-07)
Postacidotic arrhythmias have been associated to increased sarcoplasmic reticulum (SR) Ca2 + load and Ca2 +/calmodulin-dependent protein kinase II (CaMKII) activation. However, the molecular mechanisms underlying these ...
IL-33 alarmin and its active proinflammatory fragments are released in small intestine in Celiac disease
(Frontiers Media, 2020-10-08)
Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While localized in the nucleus acts as a gene regulator, it can be also ...
Differential cholinoceptor modulation of nitric oxide isoforms in experimentally-induced inflammation of dental pulp tissue
(Wiley Blackwell Publishing, Inc, 2009-06)
Aim The aim of the study was to investigate the role of muscarinic acetylcholine receptor (mAChR) activity in the regulation of endothelial (e), neuronal (n) and inducible (i) nitric oxide synthase (NOS) activity and ...
Cytokines use different intracellular mechanisms to upregulate the membrane expression of CX 3 CR1 in human monocytes
(Pergamon-Elsevier Science Ltd, 2019-04)
Membrane expression of fractalkine (CX 3 CL1)-receptor (CX 3 CR1) is relevant in monocytes (Mo) because CX 3 CR1-CX 3 CL1 interactions might participate on both, homeostatic and pathologic conditions. We have previously ...
The nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide dampens lipopolysaccharide-induced transcriptomic changes in macrophages
(Birkhauser Verlag Ag, 2018-06)
Objective: M1-like inflammatory phenotype of macrophages plays a critical role in tissue damage in chronic inflammatory diseases. Previously, we found that the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) ...
Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells
(Pergamon-Elsevier Science Ltd, 2020-12)
Understanding the effects of Bisphenol A (BPA) on early germ cell differentiation and their consequences in adult life is an area of growing interest in the field of endocrine disruption. Herein, we investigate whether ...
Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis by Differentially Modulating the Transcriptomic Response of Intestinal Epithelial Cells
(Frontiers Media S.A., 2020-09-17)
Immunobiotics have emerged as a promising intervention to alleviate intestinal damage in inflammatory bowel disease (IBD). However, the beneficial properties of immunobiotics are strain dependent and, therefore, each strain ...