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SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress
(Elsevier Science Inc, 2019-11)
In order to adequately respond to stressful stimuli, glucocorticoids (GCs) target almost every tissue of the body. By exerting a negative feedback loop in the hypothalamic–pituitary–adrenal (HPA) axis GCs inhibit their own ...
Targeting progesterone receptors in breast cancer
(Elsevier Academic Press Inc, 2013)
Hormone receptors represent the earliest biomarkers used in breast cancer not only as prognosis markers but, in addition, to decide treatment. However, mostly estrogen receptors have been used as therapeutic targets. There ...
Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression
(American Physiological Society, 2012-01)
Since anterior pituitary expresses prolactin receptors, prolactin secreted by lactotropes could exert autocrine or paracrine actions on anterior pituitary cells. In fact, it has been observed that prolactin inhibits its ...
Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation
(Elsevier Science, 2019-03)
Histamine [2-(4-Imidazolyl)-ethylamine] modulates different biological processes, through histamine H1 and H2 receptors, and their respective blockers are widely used in treating allergic and gastric acid-related disorders. ...
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators
(Cell Press, 2018-01-02)
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The ...
Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
(Elsevier Science Inc, 2018-05)
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role ...
Receptores Fcγ y autoinmunidadFcγ receptors and autoimmunity
(Asociación Colombiana de Medicina InternaBiología Celular y Molecular CIB U. de A. U. del RosarioBogotá, Colombia, 2021)
Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
(Academic Press Inc Elsevier Science, 2018-04)
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors were identified as mineralocorticoid ...
Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland
(Elsevier Science, 2002-08)
Muscarinic receptors play an important role in secretory and vasodilator responses in rat salivary glands. Nitric oxide synthase (NOS) activity was found coupled to muscarinic receptor activation as well as to nitric ...
Signaling pathways that regulate Trypanosoma cruzi infection and immune response
(Elsevier Science, 2020-05-01)
Current understanding of key cellular pathways, which are activated by the interaction between T. cruzi and host immunity, is crucial for controlling T. cruzi infection and also for limiting the development of the ...