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Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
(Taylor & Francis, 2015-05)
Pathogens have evolved highly specialized mechanisms to infect hosts. Several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. Once internalized, they hijack the molecular machinery of ...
ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1
(Academic Press Inc Elsevier Science, 2015-11)
ApoER2 and its ligand Reelin participate in neuronal migration during development. Upon receptor binding, Reelin induces the proteolytic processing of ApoER2 as well as the activation of signaling pathway, including small ...
Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins
(American Association For The Advancement Of Science, 2011)
Áreas de riesgo agroclimático para cuatro rotaciones de cultivos de la región oriental agropecuaria de La Pampa (Argentina) = Agroclimatic risk areas for four crop rotation schedules in the agricultural eastern region of La Pampa (Argentina)
(Facultad de Agronomía, UNLPam, 2014)
Los riesgos climáticos son, en esencia, la probabilidad de ocurrencia de eventos de baja
frecuencia que más tarde o más temprano terminan desarrollándose, guiados por su particular periodicidad. Estos riesgos se convierten ...
Drug vulnerabilities and disease prognosis linked to the stem cell-like gene expression program triggered by the RHO GTPase activator VAV2 in hyperplastic keratinocytes and head and neck cancer
(Molecular Diversity Preservation International, 2020-09)
We have recently shown that VAV2, a guanosine nucleotide exchange factor that catalyzes the stimulation step of RHO GTPases, is involved in a stem cell-like (SCL) regenerative proliferation program that is important for ...
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
(Cell Press, 2017-11)
Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their ...
A feed-forward mechanism involving the NOX complex and RyR-mediated ca2 + release during axonal specification
(Society for Neuroscience, 2016-10)
Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2 +, a broad intracellular second messenger, promotes both Rac1 ...
Timing of novel drug 1a-116 to circadian rhythms improves therapeutic effects against glioblastoma
(Multidisciplinary Digital Publishing Institute, 2021-07)
The Ras homologous family of small guanosine triphosphate-binding enzymes (GTPases) is critical for cell migration and proliferation. The novel drug 1A-116 blocks the interaction site of the Ras-related C3 botulinum toxin ...
The early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis
(American Society for Biochemistry and Molecular Biology, 2022-06)
The actin cytoskeleton reorganization during sperm capacitation is essential for the occurrence of acrosomal exocytosis (AR) in several mammalian species. Here, we demonstrate that in mouse sperm, within the first minutes ...