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FMNL1 promotes proliferation and migration of leukemia cells
(Federation Amer Soc Exp BiolBethesdaEUA, 2013)
Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines
(Bentham Science Publishers, 2013-09)
Rho GTPases play a key role in the regulation of multiple essential cellular processes, including actin dynamics, gene transcription and cell cycle progression. Aberrant activation of Rac1, a member of Rho family of small ...
Spatiotemporal analysis of RhoA and Rac1 activation for cell polarization
(2017)
Introduction: The Rho-family of GTPases are critical in regulating cytoskeletal rearrangements during cell migration. It have been described that Rac1 is involved in lamellipodia formation and RhoA in cell contractility ...
Spatiotemporal analysis of RhoA and Rac1 activation for cell polarization
(2016)
Introduction: The Rho-family of GTPases are critical in regulating cytoskeletal rearrangements during cell migration. It have been described that Rac1 is involved in lamellipodia formation and RhoA in cell contractility ...
Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer
(Wiley VCH Verlag, 2021-03)
The Rho GTPase Rac1 is involved in the control of cytoskeleton reorganization and other fundamental cellular functions. Aberrant activity of Rac1 and its regulators is common in human cancer. In particular, deregulated ...
El coactivador de receptores nucleares RAC3 tiene un rol protector de la apoptosis inducida por distintos estimulosRAC3 nuclear receptor coactivator has a protective role in the apoptosis induced by different stimuli
(Medicina (Buenos Aires), 2007-12)
RAC3 pertenece a la familia de coactivadores de receptores nucleares p160, y se encuentra sobre-expresado en varios tumores. Demostramos previamente que RAC3 es coactivador del factor de transcripción anti-apoptótico NF-κB. ...
Control of cell adhesion and migration by podocalyxin. Implication of Rac1 and Cdc42
(Elsevier, 2013-02-08)
Podocalyxin (PODXL) is a type I membrane sialomucin, originally described in the epithelial cells (podocytes) of kidney glomeruli. PODXL is also found in extra-renal tissues and in certain aggressive tumors, but its precise ...