Search
Now showing items 21-30 of 2219
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
(Impact Journals LLC, 2017-10)
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity ...
RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
(BioMed Central, 2017-11)
Background: RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition ofapoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents.The ...
The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses to salt intake
(Oxford University Press, 2015)
© American Journal of Hypertension, Ltd 2014. All rights reserved.Background Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect ...
Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion
(Company of Biologists Ltd, 2014)
Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
Pirólisis de residuos de cosecha de caña de azúcar (RAC) como alternativa de aprovechamiento en procesos de cogeneración [recurso electrónico]
(2015-09-04)
El presente documento consigna los principales resultados del proyecto de investigación cuyo objetivo principal es el de determinar el potencial de aplicación de la ruta termoquímica de la pirólisis, a la biomasa residual ...
The Expression of RAC1 and Mineralocorticoid Pathway- Dependent Genes are Associated With Different Responses to Salt Intake
(Oxford University Press, 2015)
BACKGROUND
Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as ...
1-42 B-amyloid peptide (AB1-42) requires PDK1/nPKCs/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013-01)
1–42 β-Amyloid (Aβ1–42) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve loss of ...
RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis
(Elsevier Science, 2007-10)
The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human chronic myeloid leukemia cells K562, which are normally resistant ...
Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics
(Elsevier Science Inc, 2018-04)
Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance ...
Ractopamina y nivel de proteína de la dieta, respuesta productiva y características de la carcasa de cuyes (Cavia porcellus)
(Universidad Nacional Agraria La Molina, 2017)
El objetivo del presente trabajo fue determinar el efecto del Clorhidrato de Ractopamina (RAC) y el nivel de proteína de la dieta sobre la respuesta productiva y características de la carcasa de cuyes (Cavia porcellus). ...