Search
Now showing items 21-30 of 3109
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
(Landes Bioscience, 2014)
© Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway
(Elsevier Science Inc, 2016-08)
Recently, we have reported that the IL-2-stimulated T cells activate PKCθ in order to phosphorylate the serine residues of αPIX-RhoGEF, and to switch on the Rac1/PYGM pathway resulting in T cell migration and proliferation. ...
RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
(BioMed Central, 2017-11)
Background: RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition ofapoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents.The ...
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
(Impact Journals LLC, 2017-10)
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity ...
The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses to salt intake
(Oxford University Press, 2015)
© American Journal of Hypertension, Ltd 2014. All rights reserved.Background Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect ...
Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion
(Company of Biologists Ltd, 2014)
Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
Pirólisis de residuos de cosecha de caña de azúcar (RAC) como alternativa de aprovechamiento en procesos de cogeneración [recurso electrónico]
(2015-09-04)
El presente documento consigna los principales resultados del proyecto de investigación cuyo objetivo principal es el de determinar el potencial de aplicación de la ruta termoquímica de la pirólisis, a la biomasa residual ...
The Expression of RAC1 and Mineralocorticoid Pathway- Dependent Genes are Associated With Different Responses to Salt Intake
(Oxford University Press, 2015)
BACKGROUND
Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as ...
The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses to salt intake
(Oxford University Press, 2015-06)
Background Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as hemoxigenase-1 ...
1-42 B-amyloid peptide (AB1-42) requires PDK1/nPKCs/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013-01)
1–42 β-Amyloid (Aβ1–42) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve loss of ...