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Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells
(Dove Press, 2014-07)
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases ...
Aβ1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases
(2007)
A number of psychiatric and neurodegenerative disorders, such as Alzheimer's disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced by ...
Crosstalk between rac1-mediated actin regulation and ros production
(2018)
The small RhoGTPase Rac1 is implicated in a variety of events related to actin cytoskeleton rearrangement. Remarkably, another event that is completely different from those related to actin regulation has the same relevance; ...
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake
(2015)
Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as hemoxigenase-1 (HO1) ...
¿Es factible en Colombia la implementación de un sistema de integración aeronáutica basado en dirigibles híbridos?
A lo largo del documento veremos como las nuevas tecnologías en dirigibles híbridos pueden potencializar el desarrollo de las poblaciones más vulnerables del territorio Colombiano. El análisis está orientado a ver cómo ...
Study of the catalytic behavior of the homo- and copolymerization of 1-octadecene with the racemic metallocene catalysts rac-et(ind)(2)zrcl2 and rac-me2si(ind)(2)zrcl2.
(SOCIEDAD CHILENA DE QUIMICA, 1999)
Catalytic racemic metallocenes of othe type rac-X(Ind)(2)ZrCl2 (where X = union among indenyl rings, of the type -CH2-CH2-, (CH3)(2)Si- and (CH3)(2)C-, and Ind = indenyl) have shown a high catalytic activity for the ...
Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
(Sociedad de Biología de Chile, 2002)
Los riesgos en la seguridad operacional por la ausencia de despachadores de vuelo de helicópteros en Colombia
(Especialización en Administración AeronáuticaFacultad de Ciencias EconómicasUniversidad Militar Nueva Granada, 2020-10-25)
En los Reglamentos Aeronáuticos de Colombia (RAC) RAC 65, RAC 135 y RAC 141, se establecen los parámetros de entrenamiento para los despachadores de vuelo, referenciado únicamente para aviones. En Colombia, el transporte ...
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
(Landes Bioscience, 2014)
© Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway
(Elsevier Science Inc, 2016-08)
Recently, we have reported that the IL-2-stimulated T cells activate PKCθ in order to phosphorylate the serine residues of αPIX-RhoGEF, and to switch on the Rac1/PYGM pathway resulting in T cell migration and proliferation. ...