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Metabolic Connection between Incretins and Pulmonary Hypertension
(Biomed Central Ltd, 2015-07-01)
Studies show that at least half the adult population is overweight in most countries. Recent case reports have shown the important metabolic potential of the pathophysiology of PAH. Many cases of PAH, etiologically classified ...
Updated Clinical Classification of Pulmonary Hypertension
(ELSEVIER SCIENCE INC, 2009)
The aim of a clinical classification of pulmonary hypertension (PH) is to group together different manifestations of disease sharing similarities in pathophysiologic mechanisms, clinical presentation, and therapeutic ...
2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
(American Physiological Society, 2016)
© 2016 the American Physiological Society. Calcium signaling through store-operated channels (SOC) is involved in hypoxic pulmonary hypertension. We determined whether a treatment with 2-aminoethyldiphenylborinate (2-APB), ...
Survival of patients with pulmonary arterial hypertension after the advent of specific pulmonary vasodilator therapies
(Soc. Médica Santiago, 2016)
Background: Pulmonary arterial hypertension (PAH) is a rare and progressive disease. Long-term survival remains poor despite of advances in specific vasodilator therapy. Aim: To describe the survival rate in a cohort of ...
Paracoccidioidomycosis due to Paracoccidioides lutzii complicated with adrenal injury and pulmonary arterial hypertension
(Inst Medicina Tropical Sao Paulo, 2020-01-01)
Paracoccidioidomycosis caused by Paracoccidioides lutzii is endemic in the Midwest of Brazil and its clinical spectrum is still little known due to the recent identification of this fungal species. A patient resident in ...
Melatonin decreases pulmonary vascular remodeling and oxygen sensitivity in pulmonary hypertensive newborn lambs
(2018)
Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...
Purinergic signaling as alternative pathway to treat adult pulmonary arterial hypertension.
(2016)
INTRODUCTION: For a long time, the vasoactivity of pulmonary veins has been debated. Increasing evidences about the role of pulmonary veins to the total pulmonary vascular resistance has been particularly well supported ...
Purinergic-dependent contraction of small intrapulmonary veins: role in a pulmonary arterial hypertension rat model
(2016)
Abstract Body : Background: For a long time, the vasoactivity of pulmonary veins has been debated. Increasing
evidences about the role of pulmonary veins to the total pulmonary vascular resistance has been particularly ...
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells
(Elsevier, 2017)
Chronic hypoxia exacerbates proliferation of pulmonary arterial smooth muscle cells (PASMC), thereby reducing the lumen of pulmonary arteries. This leads to poor blood oxygenation and cardiac work overload, which are the ...
Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension
(2016)
BACKGROUND: Right atrium function and ventricular function have significant prognostic value in pulmonary arterial hypertension patients. Acute changes in right ventricular synchrony and right atrium function postiloprost ...