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Mostrando ítems 1301-1310 de 3791
Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo
(Elsevier, 2017-09)
Intercellular communication is crucial in multiple aspects of cell biology. This interaction can be mediated by several mechanisms including extracellular vesicle (EV) transfer. EV secretion by parasites has been reported ...
Application of computer-aided drug repurposing in the search of new cruzipain inhibitors: discovery of amiodarone and bromocriptine inhibitory effects
(American Chemical Society, 2013-06)
Cruzipain (Cz) is the major cystein protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. From a 163-compound dataset, a 2D-classifier capable of identifying Cz inhibitors was obtained and ...
Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi
(BioMed Central, 2009-05)
Background. Trypanosoma cruzi, a kinetoplastid protozoan parasite that causes Chagas disease, infects approximately 15 million people in Central and South America. In contrast to the substantial in silico studies of the ...
Detection of Trypanosoma evansi infection in wild capybaras from Argentina using smear microscopy and real-time PCR assays
(Elsevier, 2014-05)
Trypanosoma evansi is a flagellated protozoan that parasitizes a wide variety of mammals, occasionally including humans. In South America, it infects horses, cattle, buffaloes, dogs and wild mammals, causing a disease known ...
Neospora caninum is a cause of perinatal mortality in axis deer (Axis axis)
(Elsevier, 2014-01)
Neospora caninum is a worldwide distributed protozoan that may cause neuromuscular disease in dogs and reproductive failure in domestic and wild ruminants. One axis fawn (Axis axis) and four neonates from the same deer ...
Catalytic activity of a novel serine/threonine protein phosphatase PP5 from Leishmania majorActivite´ catalytique d’une nouvelle phosphatase de prote´ine se´rine/thre´onine PP5 de Leishmania major
(Princeps Editions, 2014-06)
Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. Our knowledge of protein phosphatases (PPs) and their implication in signaling events is very limited. Here we report the ...
Active and passive mechanisms drive secretory granule biogenesis during differentiation of the intestinal parasite Giardia lamblia
(American Society for Biochemistry and Molecular Biology, 2006-06-30)
The parasitic protozoan Giardia lamblia undergoes important changes to survive outside the intestine of its host by differentiating into infective cysts. During encystation, three cyst wall proteins (CWPs) are specifically ...
All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae
(American Society for Cell Biology, 2008-07)
The transfer of lipid-linked oligosaccharide to asparagine residues of polypeptide chains is catalyzed by oligosaccharyltransferase (OTase). In most eukaryotes, OTase is a hetero-oligomeric complex composed of eight different ...
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
(Elsevier Gmbh, 2014-07)
BACKGROUND: Chagas disease or American Trypanosomiasis is caused by the flagellated protozoan parasite Trypanosoma cruzi (T. cruzi) and is recognized by the WHO as one of the world's 17 neglected tropical diseases. Only ...
Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity
(Taylor & Francis, 2013-07)
Autophagy is a cell process that in normal conditions serves to recycle cytoplasmic components and aged or damaged organelles. The autophagic pathway has been implicated in many physiological and pathological situations, ...