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Poloxamer micellar system for intra-articular injection of 15-deoxy-Δ12,14-prostaglandin J2 with improved bioavailability and anti-inflammatory properties in the temporomandibular joint of rats
(2020-06-15)
Painful conditions of the temporomandibular joint (TMJ) are challenging to manage and most attempts often result in unsatisfactory outcomes. In such context, nanocarrier systems, such as polymeric micelles, have been showing ...
Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia
(American Chemical Society, 2021-02)
Loperamide is a μ-opioid agonist with poor gastrointestinal absorption, mainly because of its modest aqueous solubility and being a P-glycoprotein (Pgp) efflux substrate. Nevertheless, studies associated with therapeutic ...
Effect of Polymer Micelles on Antifungal Activity of Geranylorcinol Compounds against Botrytis cinerea
(American Chemical Society, 2015)
Evaluation of the performance of an ophthalmic thermosensitive hydrogel containing combination of suramin and bevacizumab
(Bentham Science Publishers, 2016-12)
Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions ...
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...
DESENVOLVIMENTO TECNOLÓGICO, CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE DISPERSÕES SÓLIDAS CONTENDO ÁCIDO FERÚLICO
(UNIVERSIDADE ESTADUAL DE PONTA GROSSABRFarmacos, Medicamentos e Biociências Aplicadas à FarmáciaPrograma de Pós Graduação Ciências FarmacêuticasUEPG, 2017)
Budesonide-hydroxypropyl-beta-cyclodextrin inclusion complex in binary poloxamer 407/403 system for ulcerative colitis treatment: A physico-chemical study from micelles to hydrogels
(Elsevier B.V., 2016-02-01)
Budesonide (BUD) is a glucocorticoid widely used for the treatment of ulcerative colitis. In this work, we propose the study of the system BUD-HP-beta-CD inclusion complex incorporated into PL 407 and PL407-PL403 ...