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Downregulation of TREM-like transcript (TLT)-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia
(Ferrata Storti Foundation, 2018-12)
Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familialplatelet disorder with predisposition to acute myelogenous leukemia. Multiple aspects ofplatelet function are impaired in these patients, ...
Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer
(Springer/Plenum Publishers, 2019-06)
Alzheimer’s disease (AD) is associated to depressed brain energy supply and impaired cortical and hippocampal synaptic function. It was previously reported in McGill-R-Thy1-APP transgenic (Tg(+/+)) rats that Aβ deposition ...
Activation of human platelets by a TLR2 agonist induces aggregation, tissue factor dependent procoagulant activity, thrombin generation and increased adhesion to endothelial cells.
(2016)
In addition to its well known function in hemostasis, the involvement of platelets in innate immunity is
today widely accepted. Acute inflammation in response to bacterial infection, results in hemostatic
abnormalities ...
Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms
(Frontiers Research Foundation, 2019-06-14)
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts. They encompass three closely ...
Lipopolysaccharide treatment reduces rat platelet aggregation independent of intracellular reactive-oxygen species generation
(Informa HealthcareLondon, 2012)
Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets
(Wiley, 2014-05)
Background: Familial platelet disorder with a predisposition to acute myelogenous leukemia (FPD/AML) is an inherited platelet disorder caused by a germline RUNX1 mutation and characterized by thrombocytopenia, a platelet ...
Platelet hyperaggregability in high-fat fed rats: A role for intraplatelet reactive-oxygen species production
(Biomed Central Ltd., 2012-01-16)
c Background: Adiposity greatly increases the risk of atherothrombotic events, a pathological condition where a chronic state of oxidative stress is reported to play a major role. This study aimed to investigate the ...