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Cardioprotection of benzolamide in a regional ischemia model: Role of ENOS/NO
(Academic Press Inc Elsevier Science, 2018-10)
Background: Recent studies from our laboratory show the cardioprotective action of benzolamide (BZ, carbonic anhydrase inhibitor) against ischemia-reperfusion injury. However, the mechanisms involved have not been fully ...
Role of PTHrP in human intestinal Caco-2 cell response to oxidative stress
(Elsevier, 2013-07)
We have previously demonstrated that parathyroid hormone (PTH) induces apoptosis in human colon adenocarcinoma Caco-2 cells but the effects of its tumoral analog PTH-related peptide (PTHrP) in this cell line are still ...
Extracellular-regulated kinase and p38 mitogen-activated protein kinases are involved in the antiapoptotic action of 17β-estradiol in skeletal muscle cells
(BioScientifica, 2010-08)
17β-Estradiol (E2) stimulates the mitogen-activated protein kinases (MAPKs) in various cellular types.We have shown that the hormone activates extracellular-regulated kinase (ERK) and p38 MAPK in skeletal muscle cells. ...
GH/STAT5 signaling during the growth period in livers of mice overexpressing GH
(Bioscientifica, 2015-04)
GH/STAT5 signaling is desensitized in the liver in adult transgenic mice overexpressing GH; however, these animals present greater body size. To assess whether the STAT5 pathway is active during the growth period in the ...
Differential contribution of HP1 proteins to DNA end resection and homology-directed repair
(Taylor & Francis, 2013-02)
Heterochromatin protein 1 paralogs (HP1α, β and γ in mammals) are not only central in heterochromatin organization, but have also been linked to transcriptional activation at euchromatic regions, maintenance of telomere ...
Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration
(Nature Publishing Group, 2019-02)
Hepatocellular carcinoma (HCC) is a highly metastatic cancer with very poor prognosis. AMP activated kinase (AMPK) constitutes a candidate to inhibit HCC progression. First, AMPK is downregulated in HCC. Second, glucose ...
DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration
(Royal Society Of Chemistry, 2015-09)
Previous work by our group demonstrated the key role of iron in Schwann cell (SC)maturation through an increase in cAMP, PKA activation and CREB phosphorylation. These studies opened the door to further research on a ...
Epicatechin reduces blood pressure increase in high fructose-fed rats: effects on the determinants of nitric oxide bioavailability
(Elsevier Science Inc, 2015-07)
This work investigated the blood pressure (BP) lowering effect of the flavanol (─)-epicatechin in a model of metabolic syndrome. Rats were fed a regular chow diet without (Control) or with 10% (w/v) fructose in the drinking ...
Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage
(Nature Publishing Group, 2015-04)
Background: The mechanisms by which stress hormones impact triple-negative breast cancer (TNBC) etiology and treatment are unclear. We have previously shown that stress hormones, cortisol, and catecholamines induce rapid ...
Lysine acetylation modulates mouse sperm capacitation
(Nature Publishing Group, 2018-12)
Mammalian sperm are unable to fertilize the egg immediately after ejaculation. To gain fertilization competence, they need to undergo a series of modifications inside the female reproductive tract, known as capacitation. ...