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The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases
(Science Advances is the American Association for the Advancement of Science, 2021-11)
Selected patients with brain metastases (BM) are candidates for radiotherapy. A lactatogenic metabolism, common in BM, has been associated with radioresistance. We demonstrated that BM express nitric oxide (NO) synthase 2 ...
Alterations of the extracellular matrix of lung during zinc deficiency
(Cambridge University Press, 2012-07)
Suboptimal intake of Zn is one of the most common nutritional problems worldwide. Previously, we have shown that Zn deficiency (ZD) produces oxidative and nitrosative stress in the lung of rats. We analyse the effect of ...
Galactomannan as a potential modulator of intestinal ischemia–reperfusion injury
(Academic Press Inc Elsevier Science, 2020-05-01)
Background: Galactomannan (GAL), a polysaccharide present on the cell wall of several fungi, has shown an ability to modulate inflammatory responses through the dectin-1 receptor in human macrophages. However, studies ...
Iron-sulfur repair YtfE protein from Escherichia coli: Structural characterization of the di-iron center
(Springer, 2008-06)
YtfE was recently shown to be a newly discovered protein required for the recovery of the activity of iron-sulfur-containing enzymes damaged by oxidative and nitrosative stress conditions. The Escherichia coli YtfE purified ...
Nitosylation: an adverse factor in Hemolytic Uremic Syndrome. Antitoxin effect of Ziziphus mistol Griseb
(Elsevier, 2013-02)
Toxins of Escherichia coli (STEC) causing Uremic Hemolytic Syndrome (UHS) generate oxidative stress in human blood with more production of nitric oxide (NO) than reactive oxygen species (ROS). Shiga toxin (Stx) together ...
Non-Steroidal treatments as new strategies for uveitis treatment
(Nova Science Publishers, 2017)
Uveitis refers to a group of conditions defined by intraocular inflammation, that can be infectious or non-infectious, being the latter the most common. Uveitis hasa very important socio economics impact because it affects ...
Role of PheE15 Gate in Ligand Entry and Nitric Oxide Detoxification Function of Mycobacterium tuberculosis Truncated Hemoglobin N
(Public Library of Science, 2012-11)
The truncated hemoglobin N, HbN, of Mycobacterium tuberculosis is endowed with a potent nitric oxide dioxygenase (NOD) activity that allows it to relieve nitrosative stress and enhance in vivo survival of its host. Despite ...
Living in an Extremely Polluted Environment: Clues from the Genome of Melanin-Producing Aeromonas salmonicida subsp. pectinolytica 34melT
(American Society for Microbiology, 2015-05-29)
Aeromonas salmonicida subsp. pectinolytica 34melT can be considered an extremophile due to the characteristics of the heavily polluted river from which it was isolated. While four subspecies of A. salmonicida are known ...
Investigação dos processos neuroinflamatórios em um modelo murino de encefalopatia hepática por falência hepática aguda
(Universidade Federal de Minas GeraisUFMG, 2013-02-04)
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that results from acute liver failure (ALF) and one of its major complications. HE emergence implies an increase in the severity and risk of death in these patients. ...
Biopatologia do Helicobacter pylori
(Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2003-01-01)
A infecção pelo Helicobacter pylori (H. pylori) induz inflamação persistente na mucosa gástrica com diferentes lesões orgânicas em humanos, tais como gastrite crônica, úlcera péptica e câncer gástrico. Os fatores determinantes ...