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Avaliação ecotoxicológica do fumarato de tenofovir desoproxila sobre Biomphalaria glabrata, in vivo e in vitro.
(Universidade Federal de Minas GeraisBrasilFARMACIA - FACULDADE DE FARMACIAPrograma de Pós-Graduação em Medicamentos e Assistencia FarmaceuticaUFMG, 2022-10-17)
Tenofovir Disoproxil Fumarate (TDF) is a drug commonly used in the treatment of human immunodeficiency virus (HIV). Due to its resistance to metabolism by biological systems, up to 80% of the drug dose can be eliminated ...
Óxido nítrico sintase neuronal (nNOS) na doença arterial coronariana humana: correlação com a formação da placa aterosclerótica
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-09-10)
Coronary artery disease (CAD) is characterized by inadequate blood supply to the heart muscle, resulting from the narrowing of the arteries, mostly caused by atherosclerosis. Atherosclerosis, a chronic inflammatory process ...
Leukotrienes Produced in Allergic Lung Inflammation Activate Alveolar Macrophages
(Karger, 2010-01-01)
It has been well-documented that leukotrienes (LTs) are released in allergic lung inflammation and that they participate in the physiopathology of asthma. A role for LTs in innate immunity has recently emerged: Cys-LTs ...
Efeito in vitro do haloperidol e risperidona na ativação inflamatória de macrófagos RAW 264.7
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2015-04-10)
Introduction: Antipsychotic drugs, such as haloperidol (typical) and risperidone (atypical)
increase the risk of obesity and other endocrine disturbs in psychiatric patients when used in
long term treatments. There is ...
Evidence for the participation of calcium in non-genomic relaxations induced by androgenic steroids in rat vas deferens
(Nature Publishing Group, 2008-03-01)
Background and purpose: Androgens cause non-genomic relaxation in several smooth muscle preparations. However, such an effect has not been investigated in rat vas deferens yet. Our purpose was to study the effect of ...
Caveolin-1-mediated tumor suppression is linked to reduced hif1α s-nitrosylation and transcriptional activity in hypoxia
(2020-09)
Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...