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In vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodies
(2018)
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the
African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and
α-neurotoxins associated with high ...
Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies
(2013-07)
The composition and toxicological profile of the venom of the rattlesnake Crotalus simus in
Mexico was analyzed at the subspecies and individual levels. Venoms of the subspecies C. s.
simus, C. s. culminatus and C. s. ...
Mipartoxin-I, a novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae)
(2012)
The major venom component of Micrurus mipartitus, a coral snake distributed from
Nicaragua to northern South America, was characterized biochemically and functionally.
This protein, named mipartoxin-I, is a novel member ...
Elapid venom toxins: multiple recruitments of ancient scaffolds
(1999-01)
Nigroxins A and B, two myotoxic phospholipases A2 (PLA2s) from the venom of the American elapid Micrurus nigrocinctus, belong to a new PLA2 subclass. Their primary structures were established and compared with those of ...
Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion
(1994-11)
A detailed behavioral analysis during the first postoperative week was performed in rats which had sustained various degrees of unilateral neostriatal dopamine (DA) lesions by administration of the neurotoxin 6-hydroxydopamine ...
Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab0)2 and whole IgG antivenoms
(2016-01-22)
The neuromuscular junction activity of Oxyuranus scutellatus venom and its presynaptic neurotoxin, taipoxin, and their neutralization by two antivenoms were examined in mouse phrenic nerve-diaphragm preparations. The action ...
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus
(1997-04)
Therapeutic antisera against Micrurus nigrocinctus venom were tested for protection against lethality, as well as for inhibition of the nicotinic acetylcholine receptor (AchR)-binding and neutralization of phospholipase ...
Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping
(2017-07)
Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies
purified from the blood of hyper-immunized animals. Knowledge on antibody recognition
sites (epitopes) on snake venom proteins ...
Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom
(2016-09-15)
A chicken-derived antivenom (ChDAv) towards taipan snake (Oxyuranus scutellatus) venom was produced
by purifying anti-taipan IgY from egg yolks of hens immunized with taipan venom. The productivity,
antivenomic profile, ...
Mipartoxin-I, a novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae)
(2012)
The major venom component of Micrurus mipartitus, a coral snake distributed from
Nicaragua to northern South America, was characterized biochemically and functionally.
This protein, named mipartoxin-I, is a novel member ...