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Mostrando ítems 101-110 de 257
Análisis ontogenético de las bases neurobiológicas del aprendizaje contextual en roedores, a través de un abordaje comportamental, farmacológico y estructural
(2016)
Numerosas investigaciones en la última década han contribuido al avance en el
estudio del aprendizaje y la memoria, que comprenden un área de gran relevancia en
el campo de las Neurociencias. El aprendizaje contextual, ...
Estudos da competição entre laminina e ollgômeros Aβ pela ligação à PrPc e seus efeitos no ritmo circadiano
(Universidade Federal de São Paulo (UNIFESP), 2017-05-30)
Interaction between PrPC and Laminin (LN) promotes neuritogenesis via ERK1/2, while the interaction between PrPC and amyloid-beta oligomer (oAβ) triggers synaptic dysfunction via Fyn kinase, but both complexes use mGluR1 ...
Reduced expression of hippocampal GluN2A-NMDAR increases seizure susceptibility and causes deficits in contextual memory
(Frontiers Media, 2021-04)
N-methyl-D-aspartate receptors are heterotetramers composed of two GluN1 obligatory subunits and two regulatory subunits. In cognitive-related brain structures, GluN2A and GluN2B are the most abundant regulatory subunits, ...
Analysis of the NMDA in Focal Cerebral Ischemia in Rats
(SOC CHILENA ANATOMIATEMUCO, 2012)
NMDAR (N-methyl-D-aspartate receptor) is one subtype of ionotrophic glutamate receptor which is extensively distributed in the central nervous system (CNS). In the mammalian CNS, NMDAR serves prominent roles in the ...
Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-D-aspartate receptor subunits after spinal cord injury
(Elsevier Ireland, 2008-12)
Central neuropathic pain is refractory to conventional treatment and thus remains a therapeutic challenge. In this work, we used a well-recognized model of central neuropathic pain to evaluate time-dependent expression of ...
Efeito amnésico da arcaína depende da novidade e do sistema opióide
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2012-03-01)
Previous exposure to the training context disrupts glutamatergic N-methyl-Daspartate
receptor (NMDAr) antagonist-induced amnesia, indicating that novelty is
necessary for such an amnestic effect. While there are reports ...
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
(Nature Publishing Group, 2009-11)
Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was ...
Mecanismos celulares envolvidos na morte e neuroproteção deneurônios primários infectados pelo vírus da Zika
(Universidade Federal de Minas GeraisUFMG, 2018-09-04)
In 2015, Brazil was affected by an outbreak caused by zika virus (ZIKV), which is an arbovirus from the Flaviviridae family. For most individuals, ZIKV infection is asymptomatic and in most symptomatic cases clinical signs ...
Estudo do envolvimento do córtex perirrinal na reconsolidação da memória de reconhecimento de objetos
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS, 2019-03-14)
Consolidated memories can become labile when reactivated and, to persist, must
undergo a protein synthesis-dependent restabilization process called
reconsolidation. The perirhinal cortex (PER) regulates the flow of ...