Now showing items 1-10 of 819
Síntese de glicoaminoácidos de interesse biológico
(Sociedade Brasileira de Química, 2008)
This work describes the synthesis of the glycosylated amino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thr by the glycosylation reaction of the amino acid threonine with the corresponding glycosyl donors ...
A novel fission yeast platform to model N -glycosylation and the bases of congenital disorders of glycosylation Type I
(Company of Biologists, 2022-03)
Congenital disorders of glycosylation type I (CDG-I) are inherited human diseases caused by deficiencies in lipid-linked oligosaccharide (LLO) synthesis or the glycan transfer to proteins during N-glycosylation. We constructed ...
Cracking the “Sugar Code”: A Snapshot of N- and O-Glycosylation Pathways and Functions in Plants Cells
(Frontiers Media, 2021-02)
Glycosylation is a fundamental co-translational and/or post-translational modification process where an attachment of sugars onto either proteins or lipids can alter their biological function, subcellular location and ...
Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
(Pontificia Universidad Católica de Valparaíso, 2007)
Effect of ANITVNITV peptide fusion on the bioactivity and pharmacokinetics of human IFN-α2b and a hyper-N-glycosylated variant
(Elsevier Science, 2019-09)
Different strategies have been developed and successfully applied to biotherapeutics in order to improve their in vivo efficacy. The genetic fusion to natural or synthetic glycosylated peptides constitutes a promising ...
Differential O-3/O-4 selectivity in the glycosylation of N-dimethylmaleoyl-protected hexosamine acceptors: effect of a conformationally armed (superarmed) glycosyl donor
An assessment of the relative O-3/O-4 reactivities of both -methyl glycosides of N-dimethylmaleoyl (DMM) glucosamine and allosamine acceptors protected at O-6 with a benzyl group using a -glucopyranosyl conformationally ...
Glycosylation influencing on fusion activity of HA and HEF structures of influenza viruses
(Instituto de Ci??ncias da Sa??de/ Universidade Federal da Bahia, 2003-07)
Redesigning N-glycosylation sites in a GH3 β-xylosidase improves the enzymatic efficiency
Background: β-Xylosidases are glycoside hydrolases (GHs) that cleave xylooligosaccharides and/or xylobiose into shorter oligosaccharides and xylose. Aspergillus nidulans is an established genetic model and good source of ...
Critical role of evolutionarily conserved glycosylation at Asn211in the intracellular trafficking and activity of sialyltransferase ST3Gal-II
(Portland Press, 2015-07)
ST3Gal-II, a type II transmembrane protein, is the main mammalian sialyltransferase responsible for GD1a and GT1b ganglioside biosynthesis in brain. It contains two putative N-glycosylation sites (Asn92 and Asn211). Whereas ...