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Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes
(ELSEVIER SCIENCE BV, 1998-01-30)
IGF-1 increased 2-fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF-I at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, ...
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-04)
Hyperosmotic stress stimulates a rapid and pronounced apoptosis in cardiac myocytes which is attenuated by insulin-like growth factor-1 (IGF-1). Because in these cells IGF-1 induces intracellular Ca2+ increase, we assessed ...
IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress
(ACADEMIC PRESS INC, 2000-04-21)
Insulin-like growth factor-1 (IGF-1) is a natural protectant of cardiac myocytes that has been shown to improve cardiac function. The role of IGF-1 in attenuating apoptosis induced by osmotic stress (sorbitol, SOR) or by ...
IGF-1 activates polyphosphoinositide hydrolysis, protein kinase C isoforms and ERK pathway in cultured neonatal rat cardiac myocytes
(1997)
Because IGF- lisa natural cardioprotective which migh; improve cardiac function and stimulates growth and proliferation of carfiac myocytes, there is considerable interest to elucidate the molecular f!iechanisms by which ...
GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy
(Public Library Science, 2016-12-15)
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...
A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes
(SPRINGER-VERLAG, 2001-05)
In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
Molecular mechanisms of autophagy in the cardiovascular system
(Lippincott Williams and Wilkins, 2015)
Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that
is conserved from yeast to mammals. During autophagy diverse cytosolic constituents are
enveloped by double-membrane ...
IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells
(SOC ENDOCRINOLOGY, 2004-08)
We studied the effect of IGF-I and insulin on intracellular Ca2+ in primary cultured myotubes. IGF-I induced a fast and transient Ca2+ increase, measured as fluo-3 fluorescence. This response was blocked by both genistein ...
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes
(ENDOCRINE SOC, 2006-03)
Androgens are associated with important effects on the heart, such as hypertrophy or apoptosis. These responses involve the intracellular androgen receptor. However, the mechanisms of how androgens activate several membrane ...