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4-DIMETHY~INOPHENETHYLAMINE, A SENSITIVE, SPECIFIC, ELECTROCHEMICALLY DETECTABLE MONOAMINE OXIDASE-B SUBSTRATE
(Elsevier , Science Ltd., 1994-04-04)
4-Dimethylaminophenethylamine (DMAPEA) was characterized
as an MAO substrate. This compound was unaffected by
MAO-A, while its oxidation by MAO-B was linear as a
function of both time and enzyme concentration, with Km
= ...
4-DIMETHYLAMINOPHENETHYLAMINE, A SENSITIVE, SPECIFIC, ELECTROCHEMICALLY DETECTABLE MONOAMINE OXIDASE-B SUBSTRATE
(EIsevier Science Ltd., 1994-04-04)
4-Dimethylaminophenethylamine (DMAPEA) was characterized
as an MAO substrate. This compound was unaffected by
MAO-A, while its oxidation by MAO-B was linear as a
function of both time and enzyme concentration, with Km
= ...
Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: Role of oxidative stress
(Elsevier Science, 2013-12)
Fructose administration rapidly induces oxidative stress that triggers compensatory hepatic metabolic changes. We evaluated the effect of an antioxidant, R/S-α-lipoic acid on fructose-induced oxidative stress and carbohydrate ...
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model
(2018)
We have previously reported that primary hippocampal neurons exposed to synaptotoxic amyloid beta oligomers (A beta Os), which are likely causative agents of Alzheimer's disease (AD), exhibit abnormal Ca2+ signals, ...
Aldo-keto reductase and alcohol dehydrogenase contribute to benznidazole natural resistance in Trypanosoma cruzi
(Wiley Blackwell Publishing, Inc, 2017-12)
The improvement of Chagas disease treatment is focused not only on the development of new drugs but also in understanding mechanisms of action and resistance to drugs conventionally used. Thus, some strategies aim to detect ...
Avaliação do efeito da inibição do reparo de sítios abásicos na resposta inflamatória celular
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2014-08-21)
Base excision repair (BER) proteins has been associated with functions beyond DNA
repair. Apurynic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein
involved in a plethora of cellular activities, such as ...
Implications of Selective Autophagy Dysfunction for ALS Pathology
(MDPI Multidisciplinary Digital Publishing Institute, 2020-02)
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. ...
Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidioides lutzii
(Amer Soc Microbiology, 2019-11-01)
The available antifungal therapeutic arsenal is limited. The search for alternative drugs with fewer side effects and new targets remains a major challenge. Decyl gallate (G14) is a derivative of gallic acid with a range ...
Gene expression profiling analysis of copper homeostasis in Arabidopsis thaliana
(ELSEVIER, 2010)
As a result of copper essentiality for life, plants and most other organisms have developed a conserved
and complex network of proteins to handling Cu in order to prevent its deficit and to avoid its potentially
toxic ...
Acquisition and biosynthesis of saturated and unsaturated fatty acids by trypanosomatids
(Elsevier Science, 2014-04)
As components of phospholipids and glycosylphosphatidylinositol anchors, fatty acids are responsible for forming the core of biological membranes and the correct localization of proteins within membranes. They also contribute ...