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The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
Energy sources that fuel metabolic processes in protruding finger-like organelles
(Wiley, 2020)
Cells possess a variety of organelles with characteristic structure and subcellular localization intimately linked to their specific function. While most are intracellular and found in virtually all eukaryotic cells, there ...
The importance of mitophagy in maintaining mitochondrial function in U373MG cells. Bafilomycin A1 restores aminochrome-induced mitochondrial damage
(American Chemical Society, 2017)
Aminochrome, an orthoquinone formed during the dopamine oxidation of neuromelanin, is neurotoxic because it induces mitochondria dysfunction, protein degradation dysfunction (both autophagy and proteasomal systems), ...
Regulation of mitochondrial function as a promising target in platelet activation-related diseases
(Elsevier Inc., 2019)
© 2019 Elsevier Inc.Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of megakaryocytes and have a unique metabolic phenotype compared with circulating leukocytes, exhibiting a high coupling ...
The aging of ER-mitochondria communication: a journey from undifferentiated to aged cells
(Frontiers Media, 2022)
The complex physiology of eukaryotic cells requires that a variety of subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case of the endoplasmic reticulum (ER) ...
GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum–mitochondria coupling
(Elsevier, 2014)
Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of
glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic
reticulum (ER)–mitochondria ...
Calcium transport and signaling in mitochondria
(Wiley, 2017-04)
Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ...
Mitochondria, myocardial remodeling, and cardiovascular disease
(2012)
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
Inhibition of mitochondrial complex i by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
(2012)
Mitochondrial dysfunction plays a major role in the development of oxidative stress and cytotoxicity induced by non-steroidal anti-inflammatory drugs (NSAIDs). A major objective of the present study was to investigate ...
Mitochondrial distribution and meiotic progression in canine oocytes during in vivo and in vitro maturation
(Elsevier, 2011)
The objective was to evaluate mitochondrial distribution, and its relationship to meiotic development, in canine oocytes during
in vitro maturation (IVM) at 48, 72, and 96 h, compared to those that were non-matured or in ...