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Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin
(Springer New York LLC, 2016)
© 2015, Springer Science+Business Media New York.In this study, we investigated the role of adducts formation between aminochrome and tubulin and its interference in microtubules assembly and stability in aminochrome-induced ...
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination
(2007)
Microtubule-associated protein 1B (MAP1B) is the first microtubule- associated protein to be expressed during nervous system development. MAP1B belongs to a large family of proteins that contribute to the stabilization ...
DMAP‐85: A τ‐Like Protein from Drosophila melanogaster Larvae
(1995)
Abstract: Microtubule‐associated proteins (MAPs) play major regulatory roles in the organization and integrity of the cytoskeletal network. Our main interest in this study was the identification and the analysis of structural ...
Bacterial tubulins A and B exhibit polarized growth, mixed-polarity bundling, and destabilization by GTP hydrolysis
(American Society for Microbiology, 2017)
Bacteria of the genus Prosthecobacter express homologs of eukaryotic alpha- and beta-tubulin, called BtubA and BtubB (BtubA/B), that have been observed to assemble into filaments in the presence of GTP. BtubA/B polymers ...
Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly
(Elsevier, 2015)
Dihydroxynaphthyl aryl ketones 1e5 have been evaluated for their abilities to inhibit microtubule assembly
and the binding to tubulin. Compounds 3, 4 and 5 displayed competitive inhibition against
colchicine binding, and ...
Tubulin, actin, and tau protein interactions and the study of their macromolecular assemblies
(2002)
The intracellular polymerization of cytoskeletal proteins into their supramolecular assemblies raises many questions regarding the regulatory patterns that control this process. Binding experiments using the ELISA solid ...
Actin filaments modulate electrical activity of brain microtubule protein two-dimensional sheets.
(Wiley Online Library, 2020-01)
The cytoskeleton of eukaryotic cells contains networks of actin filaments and microtubules (MTs) that are jointly implicated in various cell functions, including cell division, morphogenesis, and migration. In neurons, ...
The Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B) Is Responsible for Tiam1 Binding and Rac1 Activation in Neuronal Cells
(2012)
Microtubule-associated protein 1B (MAP1B) is a neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic compartments. Acute, genetic inactivation of MAP1B leads to delayed axonal ...
Altering microtubule polymerization in Sertoli cells strongly affects their lipid metabolism
(Fundación Revista Medicina, 2017)
The aim of this work was to study the biological consequences of altering microtubule polymerization in Sertoli cells, with a special focus on their lipid metabolism. For this purpose, the effect of longterm exposures to ...
Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats
(Amer Physiological SocBethesdaEUA, 2003)