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Refining drug administration in a murine model of acute infection with Trypanosoma cruzi
(BioMed Central, 2020-10)
Background: In animal research, "refinement" refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice ...
Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1)
(Elsevier, 2008-12)
Mammalian fertilization is a complex multi-step process mediated by different molecules present on both gametes. Epididymal protein CRISP1, a member of the Cysteine-RIch Secretory Protein (CRISP) family, was identified by ...
Shiga toxin-producing Escherichia coli O157: H7 shows an increased pathogenicity in mice after the passage through the gastrointestinal tract of the same host
(Society for General Microbiology, 2012-06)
Haemolytic uraemic syndrome (HUS) is a rare but life-threatening complication of Shiga toxin (Stx)-producing Escherichia coli (STEC) infections, characterized by acute renal failure, thrombocytopenia and haemolytic anaemia. ...
Effects of exogenous sex hormones on mouse estrous cycle, vaginal microbiota and immune cells
(Springer, 2018-06)
Sex hormones are oft en administered to mice in vaginal microbial studies in order to synchronize estrous. Our objective was to evaluate the effect of estradiol-hemi succinate (EH) or medroxyprogest erone-acetate (MPA) ...
Attenuated response to methamphetamine sensitization and deficits in motor learning and memory after selective deletion of β-catenin in dopamine neurons
(Cold Spring Harbor Laboratory Press, 2012-08)
In the present study, we analyzed mice with a targeted deletion of β-catenin in DA neurons (DA-βcat KO mice) to address the functional significance of this molecule in the shaping of synaptic responses associated with motor ...
The South American Plains Vizcacha, Lagostomus maximus, as a Valuable Animal Model for Reproductive Studies
(JSciMed Central, 2016-10)
The vast majority of our understanding of the mammalianreproductive biology comes from investigations mainlyperformed in mice, rats and humans. However, evidencegathered from non-conventional laboratory models, farm andwild ...
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated with Sepsis
(Lippincott Williams, 2017-04)
Objectives: Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca2+ handling. We examined the subcellular mechanisms involved in sarcoplasmic reticulum Ca2+ loss that mediate altered ...