Buscar
Mostrando ítems 91-99 de 215
Além da atividade proteolítica das metaloproteases: atividade imunomoduladora da Thimet oligopeptidase (TOP) no tratamento do melanoma murino B16F10Nex2
(Universidade Federal de São Paulo (UNIFESP), 2017-02-28)
Previous studies in our laboratory have shown that two bacterial metalloproteases, oligopeptidase A (OpdA) and arazyme, have antitumor activity. This property was independent of their proteolytic activity, and it was ...
E-cadherina potencia a caveolina-1 como supresor de tumores y reduce su efecto promotor de metástasis
(Universidad de Chile, 2011)
Caveolina-1 es una proteína de membrana esencial en la formación de caveolas, participa en el transporte de colesterol, actúa como proteína de andamiaje en señalización y ha sido descrita como un supresor de tumores. Por ...
Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
(Elsevier Ireland, 2017-01)
Ovarian cancer is characterized by being highly metastatic, a feature that represents the main cause of failure of the treatment. This study investigated the effects of γ-secretase inhibition on the TGF-β-induced ...
A novel and alternative in vitro method using microwave to study the epithelial-stromal interactions
(Academic Journals, 2009-12)
The goal of the present work was to obtain a simple and reproducible experimental model that would maintain the characteristics of the extracellular physiological environment of breast epithelial cells, both in factors as ...
Androgen receptors in human melanoma cell lines IIB-MEL-LES and IIB-MEL-IAN and in human melanoma metastases
(Lippincott Williams, 2002-12)
The presence and characteristics of androgen receptors (AR) have been described by our group in one human melanoma cell line. We now investigated their presence in two other human melanoma cell lines, IIB-MEL-LES and ...
Antimetastatic effects of VOflavonoid complexes on A549 cell line
(Elsevier Gmbh, 2021-03)
Background: Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer and more than 90 % of mortality is due to metastasis-related deaths. Flavonoids are considered nutraceuticals due to the variety of ...
Disaccharides obtained from carrageenans as potential antitumor agents
(Nature Publishing Group, 2019-12)
Carrageenans are sulfated galactans found in certain red seaweeds with proven biological activities. In this work, we have prepared purified native and degraded κ-, ι-; and λ-carrageenans, including the disaccharides ...
Temozolomide Does Not Impair Gene Therapy-Mediated Antitumor Immunity In Syngeneic Brain Tumor Models
(American Association For Cancer Research, 2014)
PURPOSE: Glioblastoma multiforme is the most common primary brain cancer in adults. Chemotherapy with temozolomide (TMZ) significantly prolongs the survival of patients with glioblastoma multiforme. However, the three-year ...
Influence of Mast Cells on Two Murine Mammary Adenocarcinomas
(Karger, 1996)
A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of ...