Genome-scale metabolic models have become the tool of choice for the global analysis of microorganism metabolism, and their reconstruction has attained high standards of quality and reliability. Improvements in this area ...

In this work, we propose eigenvalue optimization combined with Lyapunov theory concepts to ensure stability of the Embden—Meyerhof–Parnas pathway, the pentosephosphate pathway, the phosphotransferase system and fermentation ...

The vast metabolic diversity observed in plants is the direct result of continuous evolutionary processes. There are more than 200,000 known plant secondary metabolites, representing a vast reservoir of diverse functions. ...

In the present work, we formulate parameter estimation problems for kinetic models of large-scale dynamic biotechnological systems. We propose dynamic models of increasing complexity for metabolic networks and continuous ...