Now showing items 11-14 of 14
PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy
(Wiley-liss, Div John Wiley & Sons Inc, 2016-03)
Protein kinase C (PKC) is a family of serine/threonine kinases that regulate diverse cellular functions including cell death, proliferation, and survival. Recent studies have reported that PKCδ, are involved in apoptosis ...
Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture
(Wiley-liss, Div John Wiley & Sons Inc, 2018-02)
Breast cancer human cells culture as spheroids develop autophagy and apoptosis, which promotes Trastuzumab resistance in HER2 overexpressing cells. Our aim was to study the association of the hostile environment developed ...
N4-aryl substituted thiosemicarbazones derived from 1-indanones as potential anti-tumor agents for breast cancer treatment
(Wiley-liss, Div John Wiley & Sons Inc, 2018-06)
Breast cancer is the first cause of cancer death in women. Many patients are resistant to current therapies, and even those were sensitive at first may eventually become resistant later. Thiosemicarbazones (TSCs) are ...