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Evaluation of melatonin effect on human breast cancer stem cells using a threedimensional growth method of mammospheres
(2017-01-01)
Background: The high rates of women's death from breast cancer occur due to acquired resistance by patients to certain treatments, enabling the recurrence and/or tumor growth, invasion and metastasis. It has been demonstrated ...
Cancer Stem And Progenitor-like Cells As Pharmacological Targets In Breast Cancer Treatment
(LIBERTAS ACADAUCKLAND, 2015)
Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate.
(Springer, 2013-12)
Using the M05 mouse mammary tumor model and the MCF-7 cell line, we investigated the effect of tamoxifen treatment on the fraction of breast cancer cells with self-renewing capacity both in vitro and in vivo. We found that ...
Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells Through the Activation of the MAPK/ERK Pathway
(Korean Cancer Association, 2016-12)
PURPOSE: We investigated the effects of laminin on the fraction of cells with self-renewing capacity in the estrogen-dependent, tamoxifen-sensitive LM05-E breast cancer cell line. We also determined whether laminin affected ...
Effect of Melatonin in Epithelial Mesenchymal Transition Markers and Invasive Properties of Breast Cancer Stem Cells of Canine and Human Cell Lines
(Public Library Science, 2016-03-02)
Cancer stem cells (CSCs) have been associated with metastasis and therapeutic resistance and can be generated via epithelial mesenchymal transition (EMT). Some studies suggest that the hormone melatonin acts in CSCs and ...
Avaliação da ação da melatonina em células-tronco tumorais mamárias RE-positivas tratadas com disruptores estrogênicos: verificação da via do receptor de estrógeno mediada pelo gene OCT 4
(Universidade Estadual Paulista (UNESP), 2016-05-06)
As neoplasias mamárias são os tumores de maior ocorrência em mulheres no mundo. A alta incidência deste tipo tumoral deve-se a um conjunto de fatores, entre eles o uso de hormônios, como o estrógeno e a exposição a produtos ...
Avaliação da ação da melatonina em células-tronco tumorais mamárias RE-positivas tratadas com disruptores estrogênicos: verificação da via do receptor de estrógeno mediada pelo gene OCT 4
(Universidade Estadual Paulista (UNESP), 2016)
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer
(Universidad de Murcia, 2017-07)
Fatty acid synthase (FASN) is a key lipogenic enzyme for de novo fatty acid biosynthesis and a druggable metabolic oncoprotein that is activated in most human cancers. We evaluated whether the HER2-driven lipogenic phenotype ...
Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway
(Wiley, 2015-03)
Many solid tumors contain a subpopulation of cells with stem characteristics and these are known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). These cells drive tumor growth and appear to be regulated by ...