Buscar
Mostrando ítems 1-10 de 94
New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
(Frontiers Media, 2020)
Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1) macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by relying on aerobic glycolysis and fatty acid ...
Interferon-γ, interleukins-6 and -4, and factor XIII-A as indirect markers of the classical and alternative macrophage activation pathways in chronic periodontitis
(American Academy of Periodontology, 2014)
Macrophages account for 5% to 30% of the inflammatory infiltrate in periodontitis and are activated by the classic and alternative pathways. These pathways are identified by indirect markers, among which interferon (IFN)-γ ...
Peptides conjugated to gold nanoparticles induce macrophage activation
(2009)
Macrophages that react against pathogenic organisms can also be activated with artificial nanometric units consisting of gold nanoparticles (Au NPs) with a peptide coating. Using bone marrow-derived macrophages, here we ...
The effects of immunomodulation by macrophage subsets on osteogenesis in vitro
(BioMed Central, 2016)
Background: Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the ...
Copper oxide nanoparticles recruit macrophages and modulate nitric oxide, proinflammatory cytokines and PGE(2) production through arginase activation
(Future Medicine, 2016)
Aim: In the present study, we examine the effects of copper oxide nanoparticles (CuNP) on macrophage immune response and the signaling pathways involved. Materials & Methods: A peritonitis model was used to determine in ...
Calcium sensing receptor activation in THP-1 macrophages triggers NLRP3 inflammasome and human preadipose cell inflammation
(Elsevier, 2020)
Excess adipose tissue (AT) associates with inflammation and obesity-related diseases. We studied whether calcium-sensing receptor (CaSR)-mediated NLRP3 inflammasome activation in THP-1 macrophages elevates inflammation in ...
Productive infection of Piscirickettsia salmonis in macrophages and monocyte-like cells from rainbow trout, a possible survival strategy
(2009)
Piscirickettsia salmonis is the etiologic agent of the salmonid rickettsial septicemia (SRS), an endemic disease which causes significant losses
in salmon production. This intracellular bacterium is normally cultured in ...
Serum from aged F344 rats conditions the activation of young macrophages
(ELSEVIER, 2006-03)
There is considerable controversy about the molecular mechanisms responsible for the variations in innate immunity associated with age. While in vivo, aged animals and humans react to an inflammatory signal with ail excessive ...
Maqui, Calafate, and Blueberry fruits extracts treatments suppress the pathogenic interaction amongst human adipocytes and macrophages
(IOS Press, 2020)
BACKGROUND: Obesity occurs due to a positive energy imbalance, leading to the expansion of
adipose tissue. This phenomenon triggers a chronic low-grade inflammatory state, which is associated
with comorbidities development. ...