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Desenvolvimento de novos anticorpos monoclonais humanos ANTI-CD3
(2020-06-24)
O complexo CD3 está envolvido na ativação de células T durante a resposta imune, o que o torna um alvo importante para terapia imunossupressora. O anticorpo monoclonal (mAb) murino anti-CD3, OKT3, foi o primeiro mAb aprovado ...
Interleukin-6 signalling mediates Galectin-8 co-stimulatory activity of antigen-specific CD4 T-cell response
(Wiley Blackwell Publishing, Inc, 2018-06)
Galectin-8 (Gal-8) is a mammalian lectin endowed with the ability to co-stimulate antigen-specific immune responses. We have previously demonstrated that bone-marrow-derived dendritic cells produce high levels of interleukin-6 ...
MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1
(Nature Publishing Group, 2016-03)
ErbB-2 amplification/overexpression accounts for an aggressive breast cancer (BC) subtype (ErbB-2-positive). Enhanced ErbB-2expression was also found in gastric cancer (GC) and has been correlated with poor clinical outcome. ...
Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4+ lymphocyte proliferation
(Wiley, 2011-08)
Serine leucocyte proteinase inhibitor (SLPI) is the main serine proteinase inhibitor produced by epithelial cells and has been shown to be a pleiotropic molecule with anti-inflammatory and microbicidal activities. However, ...
Characterization of antigenic tumor lysates for ex vivo activation of dendritic cells against ovarian cancerCaracterización de lisados tumorales antigénicos para la activación ex- vivo de células dendríticas contra el cáncer de ovario
(2018)
Ovarian cancer has a high mortality in advanced stages because the therapies currently in use lack effectiveness. We know that the immune system plays a fundamental role since it can favor or limit tumor growth and with ...
Retinopatías neovasculares: etiología y modelos de estudio para la búsqueda de nuevos blancos terapéuticosNeovascular retinopathies: etiology and models of study for searching new therapeutic targets
(Asociación Física Argentina, 2018-09)
Las retinopatías neovasculares se encuentran dentro de las principales causas de ceguera. En estas patologías, el déficit visual es causado en parte por un desbalance de factores angiogénicos posterior a un evento isquémico, ...
High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer
(BioMed Central, 2021-12)
Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, HER2 and Ki67 has been useful as a predictive and therapeutic tool. Also, assessment of tumor-infiltrating lymphocytes ...
Cracking the “Sugar Code”: A Snapshot of N- and O-Glycosylation Pathways and Functions in Plants Cells
(Frontiers Media, 2021-02)
Glycosylation is a fundamental co-translational and/or post-translational modification process where an attachment of sugars onto either proteins or lipids can alter their biological function, subcellular location and ...
Caracterización de la proteína microtubular de diferentes helmintos parásitos: Sus implicancias en el modo de acción de los benzimidazoles antihelmínticos
(Veterinaria Organización, 2007-12)
Los antihelmínticos benzimidazoles (BZD) desestabilizan el equilibrio tubulina-microtúbulo originando en el parásito una pérdida de la homeostasis celular, desprendimiento y muerte. Su baja toxicidad se explica por una ...
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense
(Nature, 2018-12)
Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required ...