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Type IV B pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner
(2011)
The cystic fibrosis transmembrane conductance regulator (CFTR) has been proposed as an epithelial cell receptor for the entry of Salmonella Typhi but not Salmonella Typhimurium. The bacterial ligand recognized by CFTR is ...
Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity
(Elsevier Ltd, 2014)
Endothelial dysfunction is decisive and leads to the development of several inflammatory diseases. Endotoxemia-derived sepsis syndrome exhibits a broad inflammation-induced endothelial dysfunction. We reported previously ...
O-polysaccharide plays a major role on the virulence and immunostimulatory potential of aggregatibacter actinomycetemcomitans during periodontal infection
(Frontiers Media, 2020)
Aggregatibacter actinomycetemcomitans is a Gram-negative oral bacterium with high immunostimulatory and pathogenic potential involved in the onset and progression of periodontitis, a chronic disease characterized by aberrant ...
LPS regulates the expression of glucocorticoid receptor alpha and beta isoforms and induces a selective glucocorticoid resistance in vitro
(Biomed Central Ltd., 2017)
Background: This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in ...
Lipopolysaccharide inhibits the channel activity of the P2X7 receptor
(2011)
The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such
as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells
(2013)
Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-
(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a ...
Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death
(2011)
Aims: To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons. Results: ...
Different sugar residues of the lipopolysaccharide outer core are required for early interactions of Salmonella enterica serovars Typhi and Typhimurium with epithelial cells
(Elsevier, 2011)
The role of lipopolysaccharide (LPS) in entry of Salmonella Typhimurium into epithelial cells remains
unclear. In this study, we tested the ability of a series of mutants with deletions in genes for the synthesis
and ...
Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice
(John Wiley & Sons A/S, 2011-02)
Background and Objective: Matrix metalloproteinase-8 (MMP-8) is a central mediator in chronic periodontitis. Recently developed MMP-8-deficient mice show an impaired polymorphonuclear neutrophil response and more severe ...
Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella
(SOC GENERAL MICROBIOLOGYJournal Of Medical Microbiology, vol. 57 Issue 8 p. 938-946 AUG 2008, 2008-08)
The amount of lipopolysaccharide (LPS) O antigen (OAg) and its chain length distribution are important factors that protect bacteria from serum complement. Salmonella enterica serovar Typhi produces LPS with long chain ...