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Identification of three proteins that associate in vitro with the Leishmania (Leishmania) amazonensis G-rich telomeric strand
(Blackwell Publishing LtdOxfordInglaterra, 2004)
The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
Polyamine biosynthesis enzymes are promising drug targets for the treatment of leishmaniasis, Chagas' disease and African sleeping sickness. Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine ...
Infecção natural por Leishmania infantum e Leishmania amazonensis e suas implicações para o controle da doença
(2016-01-01)
Leishmaniasis is a major public health problem worldwide. Because Leishmania can adapt to new hosts or vectors, knowledge concerning the current etiological agent in dogs is important in endemic areas. This study aimed to ...
Photodynamic therapy for American cutaneous leishmaniasis: The efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
The aim of this study was to investigate the effectiveness of Photodynamic Therapy (PDT) using Methylene Blue (MB) as the photosensitizing compound and a Light-Emitting Diode (LED) in American cutaneous leishmaniasis (ACL). ...
Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
The META cluster of Leishmania amazonensis contains both META1 and META2 genes, which are upregulated in metacyclic promastigotes and encode proteins containing the META domain. Previous studies defined META2 as a 48.0-kDa ...
Leishmania (V.) braziliensis and L. (L.) amazonensis promote differential expression of dendritic cells and cellular immune response in murine model
(WILEY-BLACKWELLHOBOKEN, 2012)
The expression of Langerhans cell (LC) and dermal dendritic cell (dDC) as well as T CD4+ and CD8+ immune responses was evaluated in the skin of BALB/c mice experimentally infected by L. (L.) amazonensis (La) and L. (V.) ...
Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA
(Elsevier B.V., 2007-06-29)
Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein involved in different events of DNA metabolism. In yeast, subunits 1 (RPA-1) and 2 (RPA-2) work also as telomerase ...
Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives
(Future Sci Ltd, 2018-09-01)
Aim: Considering the epidemiology of leishmaniasis, the emergence of resistant parasites to the approved drugs, and severe clinical manifestations, the development of novel leishmanicidal molecules has become of considerable ...