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The antifungal compound butenafine eliminates promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis
(2016-12-01)
The production of ergosterol lipid, important for the Leishmania membrane homeostasis, involves different enzymes. This pathway can be blocked to azoles and allylamines drugs, such as Butenafine. The aim of the present ...
Effect of natural naphthoquinones in BALB/c mice infected with Leishmania amazonensis and L. venezuelensis
(Trop. Med. Parasitol, 1992)
Plumbagin, 3,3’-biplumbagin and 8,8'-biplumbagin are naphthoquinones isolated by activity-directed fractionation from a Bolivian plant; Pera benensis, used in folk medicine as treatment of cutaneous leishmaniasis caused ...
In vitro and in vivo activity of benzo[ c ]phenanthridines against Leishmania amazonensis
(Georg Thieme Verlag, 2014)
Seven benzo[c]phenanthridines, synthetic or isolated from Zanthoxylum rhoifolium root bark, were evaluated against Leishmania amazonensis axenic amastigotes. Five of them were considered leishmanicidal, with IC50 values ...
Photodynamic therapy for American cutaneous leishmaniasis: The efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis
(Academic Press Inc. Elsevier B.V., 2011-08-01)
The aim of this study was to investigate the effectiveness of Photodynamic Therapy (PDT) using Methylene Blue (MB) as the photosensitizing compound and a Light-Emitting Diode (LED) in American cutaneous leishmaniasis (ACL). ...
Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice
(2016-04-01)
Experimental models of mouse paw infection with L. amazonensis show an induction of a strong inflammatory response in the skin, and parasitic migration may occur to secondary organs with consequent tissue injury. There are ...
Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis
(2018-08-27)
Background: Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive ...
Genomic organization of telomeric and subtelomeric sequences of Leishmania (Leishmania) amazonensis
(Pergamon-elsevier Science LtdOxfordInglaterra, 2005)
Natural infection of phlebotomines (Diptera: Psychodidae) by Leishmania (Leishmania) amazonensis in an area of ecotourism in Central-Western Brazil
(BioMed Central, 2015)
Abstract
Background
Bonito municipality, known as an area of ecoturism, in Mato Grosso do Sul state, Brazil, is also a focus of visceral and cutaneous leishmaniases, with ...
Leishmania amazonensis infection is reduced in macrophages treated with guanine ribonucleosides
(Elsevier Science BvAmsterdamHolanda, 1998)
Leishmania amazonensis: Xylitol as inhibitor of macrophage infection and stimulator of macrophage nitric oxide production
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
Xylitol is a sugar alcohol being explored for clinical uses. The aim was to evaluate the effects of xylitol on Leishmania amazonensis-infected J774A.1 macrophages. Macrophages were infected with L. amazonensis for 3 It, ...