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Mostrando ítems 11-20 de 254
Expressão dos genes CYP1A1, CYP1B1, CYP2A6 e CYP2E1 em fumantes com câncer bucal.
(Universidade Estadual Paulista (Unesp), 2018-02-05)
Os carcinógenos do tabaco estão relacionados a diversos tipos de câncer incluindo o carcinoma de células escamosas (CCE) bucal. Aliado ao álcool, o tabaco contribui para o desfecho desfavorável destes casos. A susceptibilidade ...
Risk assessment of the chiral pesticide fenamiphos in a human model: Cytochrome P450 phenotyping and inhibition studies
(2020-12-01)
Fenamiphos (FS) is a chiral organophosphate pesticide that is used to control nematodes in several crops. Enantioselective differences may be observed in FS activity, bioaccumulation, metabolism, and toxicity. Humans may ...
CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients
(Elsevier B.V., 2009-09-01)
Head and neck squamous cell carcinoma (HNSCC) is associated with environmental factors, especially tobacco and alcohol consumption. Most of the carcinogens present in tobacco smoke are converted into DNA-reactive metabolites ...
In vitro enantioselective inhibition of the main human CYP450 enzymes involved in drug metabolism by the chiral pesticide tebuconazole
(2021-10-15)
Tebuconazole (TEB) is a chiral triazole fungicide worldwide employed to control plant pathogens and preserve wood. People can be exposed to TEB either through diet and occupational contamination. This work investigates the ...
Avaliação da expressão dos genes cFOS, IL-1b, CYP1a1 e CYP1b1 em Danio rerio expostos a Benzo[a]pireno e tratados com ligantes do receptor P2X7
(Universidade Estadual Paulista (Unesp), 2016-01-25)
O BaP é um contaminante ambiental capaz de causar inflamação e desregulação de vias celulares. Pela ação da CYP1a1 e CYP1b1, é convertido a metabólitos mais reativos. A literatura mostra que o BaP aumenta a expressão de ...
Cyp1a1, cyp2e1 y riesgo a cáncer gástrico en una población colombiana de alta incidencia
(Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología, 2009)
El objetivo fue probar la hipótesis de que en casos y controles, de una población colombiana con alta incidencia de cáncer gástrico, muestran diferencias significativas entre las frecuencias de los polimorfismos genéticos ...
PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsy
(Mary Ann Liebert, Inc., 2008-09-01)
The aim of the present study was to examine the impact of polymorphisms in prostate-specific antigen (PSA) and androgen-related genes (AR, CYP17, and CYP19) on prostate cancer (PCa) risk in selected high-risk patients who ...
Cyp17a1 and cyp19a1 in the zebrafish testis are differentially affected by oestradiol
(2013-03-21)
Oestrogens can affect expression of genes encoding steroidogenic enzymes in fish gonads. However, little information is available on their effects at the protein level. In this context, we first analysed the expression of ...
Cyp17a1 and cyp19a1 in the zebrafish testis are differentially affected by oestradiol
(2013-03-21)
Oestrogens can affect expression of genes encoding steroidogenic enzymes in fish gonads. However, little information is available on their effects at the protein level. In this context, we first analysed the expression of ...
Una aproximación a salud personalizada: Identificación y validación de variantes genéticas asociadas con respuesta a tamoxifeno en pacientes con cáncer de seno atendidas en el HUSI
(2018-01-29)
El cáncer de seno está conformado por un grupo de enfermedades multigénicas con gran impacto a nivel mundial, además es el cáncer en mujeres con mayor tasa de mortalidad en Colombia. Para su tratamiento, existen diversas ...