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Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells
(SPRINGER, 2011)
293T and Sk-Hep-1 cells were transduced with a replication-defective self-inactivating HIV-1 derived vector carrying FVIII cDNA. The genomic DNA was sequenced to reveal LTR/human genome junctions and integration sites. One ...
Development of lentiviral vectors for inhibition of hepatitis B virus, via small interfering RNAi
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2019)
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats
(Society for the Study of Addiction, 2014)
Previous studies suggest that acetaldehyde generated from ethanol in the brain is reinforcing. The present studies tested
the feasibility of achieving a long-term reduction of chronic and post-deprivation binge ethanol ...
Multiple gene knock-down by a single lentiviral vector expressing an array of short hairpin RNAs
(Pontificia Universidad Católica de Valparaíso, 2006)
A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide
(John Wiley & Sons Ltd, 2009-05)
Background: Targeted gene transduction in vivo is the ultimate preferred method for gene delivery. We previously developed targeting lentiviral vectors that specifically recognize cell surface molecules with conjugated ...
p27Kip1 knockdown induces proliferation in the organ of Corti in culture after efficient shRNA lentiviral transduction
(Springer, 2013)
The cells in the organ of Corti do not exhibit spontaneous cell regeneration; hair cells that die after damage are not replaced. Supporting cells can be induced to transdifferentiate into hair cells, but that would deplete ...
p27Kip1 knockdown induces proliferation in the organ of Corti in culture after efficient shRNA lentiviral transduction
(Springer, 2013)
The cells in the organ of Corti do not exhibit spontaneous cell regeneration; hair cells that die after damage are not replaced. Supporting cells can be induced to transdifferentiate into hair cells, but that would deplete ...
Development of lentiviral vectors for transient and stable protein overexpression in mammalian cells: A new strategy for recombinant human FVIII (rhFVIII) production
(Elsevier, 2013-11)
Background: Recombinant protein overexpression in mammalian cells constitutes a real challenge in therapeutic protein production. Following the discovery of intron functionality in gene expression, various expression vectors ...
Development of a lentiviral vector system to study the role of the andes virus glycoproteins
(ELSEVIER SCIENCE BV, 2010)