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Deciphering the effect of an oxovanadium( iv ) complex with the flavonoid chrysin (VOChrys) on intracellular cell signalling pathways in an osteosarcoma cell line
(Royal Society of Chemistry, 2016-05)
Vanadium complexes were studied during recent years and considered as a representative of a newclass of non-platinum metal antitumor agents in combination with their low toxicity. However, a fewchallenges still remain in ...
Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene
(Federation of American Societies for Experimental Biology, 2014-12)
KLF6 is a member of the Krüppel-like factor family of transcription factors, with diverse roles in the regulation of cell physiology, including proliferation, signal transduction, and apoptosis. Mutations or down-regulation ...
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
(American Society of Hematology, 2012-01)
Diseases that cause hemolysis or myonecrosis lead to the leakage of large amounts of heme proteins. Free heme has proinflammatory and cytotoxic effects. Heme induces TLR4-dependent production of tumor necrosis factor (TNF), ...
ATP modulation of mitogen activated protein kinases and intracellular Ca2+ in breast cancer (MCF-7) cells
(Elsevier Science Inc, 2007-10-01)
In the breast tumor cell line MCF-7, extracellular nucleotides induce transient elevations in intracellular calcium concentration ([Ca2+]i). In this study we show that stimulation with ATP or UTP sensitizes MCF-7 cells to ...
Aspectos da glicobiologia de Tripanosomatídeos: as vesículas extracelulares de Trypanosoma cruzi e o lipofosfoglicano (LPG) de Leishmania amazonensis na interação parasito-hospedeiro
(Universidade Federal de Minas GeraisUFMG, 2016-11-16)
Tripanosomatid parasites are the causative agents of a wide spectrum of clinical manifestations. The parasites have an outstanding ability to avoid destruction in the hostile environments during their life cycles. Their ...
Estudo do perfil de ativação da via MAPK em células Hela induzido por formas Amastigotas Extracelulares (AEs) das cepas G e CL de Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOLOGIA GERALPrograma de Pós-Graduação em GenéticaUFMG, 2019-02-28)
Trypanosoma cruzi, the etiologic agent of Chagas Disease, which affects about 7 millions people induces MAPK pathway activation during cell invasion, favoring its entry and survival. Mitogen-activated protein kinases (MAPKs) ...
Envolvimento de p38 MAPK no ciclo de vida do Vaccinia virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2014-02-27)
Viruses rely extensively on host cell functions to complete their lifecycles. During infection, viruses co-opt signaling pathways, key regulators of cell physiology, to achieve an intracellular milieu suitable for productive ...
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient - Effects on leptin and insulin signaling pathways
(Elsevier B.V., 2007-05-01)
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic effect. However, the molecular mechanisms involved in this phenomenon are poorly characterized. In this study, we investigate ...
MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1 beta and TNF-alpha in immortalized periodontal ligament fibroblasts
(Elsevier B.V., 2005-10-01)
Matrix metalloprotease-13 (MMP-13) or collagenase-3 is involved in a number of pathologic processes such as tumor metastasis and angiogenesis, osteoarthritis, rheumatoid arthritis and periodontal diseases. These conditions ...
Epiregulin (EREG) is upregulated through an IL-1β autocrine loop in Caco-2 epithelial cells with reduced CFTR function
(Wiley, 2018)
Abstract: CFTR is a cAMP-regulated chloride channel, whose mutations produce cystic fibrosis. The impairment of CFTR activity increases the intracellular Cl- concentration, which in turn produces an increased interleukin-1β ...