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Pea3 transcription factor family members Etv4 Etv5 mediate retrograde signalling and axonal growth of DRG sensory neurons in response to NGF
(Society For Neuroscience, 2013-10)
Nerve growth factor (NGF) is a target-derived neurotrophic growth factor that controls many aspects of sensory and sympathetic neuronal development. The identification of transcription factors and downstream target genes ...
First Comparative Transcriptomic Analysis of Wild Adult Male and Female Lutzomyia longipalpis, Vector of Visceral Leishmaniasis
(Public Library Science, 2013-03-12)
Leishmaniasis is a vector-borne disease with a complex epidemiology and ecology. Visceral leishmaniasis (VL) is its most severe clinical form as it results in death if not treated. In Latin America VL is caused by the ...
Structural basis for dimer formation of the CRISPR-associated protein Csm2 of Thermotoga maritima
(Wiley-Blackwell, 2016)
The clusters of regularly interspaced short palindromic repeats (CRISPR) and the Cas (CRISPR-associated) proteins form an adaptive immune system in bacteria and archaea that evolved as an RNA-guided interference mechanism ...
PCSK9 and its clinical importance with the new therapeutic targets against dyslipidemia
(Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2012-12-01)
This is a remarkable progress; since the finding of statins, there was no new way of reducing, significantly, cholesterol and LDL fraction. It is also clear that this decrease, by statins, is related to future cardiovascular ...
Structural basis for dimer formation of the CRISPR-associated protein Csm2 of Thermotoga maritima
(Wiley-Blackwell, 2016)
The clusters of regularly interspaced short palindromic repeats (CRISPR) and the Cas (CRISPR-associated) proteins form an adaptive immune system in bacteria and archaea that evolved as an RNA-guided interference mechanism ...
The heritability of behaviors associated with the host gut microbiota
(Frontiers Media, 2020)
What defines whether the interaction between environment and organism creates a genetic memory able to be transferred to subsequent generations? Bacteria and the products of their metabolism are the most ubiquitous biotic ...
Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells
(Elsevier Ireland, 2018-10-15)
Stress activates the sympathetic nervous system and is linked to impaired fertility in man. We hypothesized that catecholamines by acting on testicular cells have a role in these events, possibly by fostering an inflammatory ...
Sprouty4 Is an Endogenous Negative Modulator of TrkA Signaling and Neuronal Differentiation Induced by NGF
(Public Library of Science, 2012-02)
The Sprouty (Spry) family of proteins represents endogenous regulators of downstream signaling pathways induced by receptor tyrosine kinases (RTKs). Using real time PCR, we detect a significant increase in the expression ...
Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation
(Endocrine Society, 2005-08)
The regulation of c-fos transcription by GH involves multiple factors, including CCAAT/enhancer binding protein (C/EBP)beta. Knockdown of C/EBPbeta by RNA interference prevents stimulation of endogenous c-fos mRNA by GH, ...
Avaliação da inibição da atividade da fosfolipase citoplasmática A2 (cPLA2) sobre o ciclo de multiplicação do Vaccinia virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2017-03-31)
Vaccinia virus (VACV), the prototype virus of the Poxviridae family, is an enveloped virus that carries out its multiplicative cycle entirely in the cytoplasm of the host cell. Throughout its multiplication cycle, VACV ...