Search
Now showing items 1-10 of 33
Differences in both inositol 1,4,5-triphosphate mass and inositol 1,4,5- triphosphate receptors between normal and dystrophic between normal and dystrophic skeletal muscle cell lines
(1998)
Human normal (RCMH) and Duchenne muscular dystrophy (RCD) cell lines, as well as newly developed normal and dystrophic murine cell lines, were used for the study of both changes in inositol 1,4,5-trisphosphate (IP3) mass ...
Mensageiros secundários relacionados à ação dos hormônios vegetais
(2011)
The current knowledge about the mechanisms of action of plant hormones is still fragmented and incomplete. However, it’s known that the regulatory action and that the potential of signal amplification of these molecules ...
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells
(Taylor and Francis Inc., 2019)
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent ...
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
(BioMed Central Ltd., 2014)
© 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice
(Elsevier B.V., 2018)
© 2018 Duchenne muscular dystrophy (DMD) is characterized by a severe and progressive destruction of muscle fibers associated with altered Ca2+ homeostasis. We have previously shown that the IP3 receptor (IP3R) plays a ...
Endoplasmic reticulum mitochondria calcium communication and the regulation of mitochondrial metabolism in cancer: a novel potential target
(Frontiers media SA, 2017)
Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to ...
Desensitization of Angiotensin II effect on [Ca2+]i, inositol triphosphate and prolactin in pituitary cells
(American Physiological Society, 2001-12)
Activation of pituitary angiotensin (ANG II) type 1 receptors (AT1) mobilizes intracellular Ca2+, resulting in increased prolactin secretion. We first assessed desensitization of AT1 receptors by testing ANG II-induced ...
Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity
(NATURE PUBLISHING GROUP, 2008)
Background and purpose: Overactive bladder is a complex and widely prevalent condition, but little is known about its physiopathology. We have carried out morphological, biochemical and functional assays to investigate the ...