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Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish
(2005)
This paper describes for the first time a massive intoxication episode due to consumption of shellfish contaminated with 7-O-acyl-derivative dinophysistoxin-1, named Dinophysistoxin-3 (DTX-3). 7-O-acyl-derivative ...
Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model
(Elsevier Ltd, 2017)
Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the ...
Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1
(Wiley-Liss, 2014)
In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties
of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
(ELSEVIER SCIENCE INC, 2010-02-15)
We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
(ELSEVIER SCIENCE BV, 2010-03)
Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
(ELSEVIER SCIENCE BV, 2011-01)
Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a G beta gamma/phosphatidylinositol 3-kinase gamma pathway in skeletal myotubes
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-04-28)
Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...
The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe-ascorbate in Caco-2 cells are similar
(AMER INST NUTRITION, 2004-02)
Inorganic iron (Fe) absorption from the diet is controlled mainly in the intestinal tract where apical Fe uptake is inversely related to the Fe content in the enterocyte. Iron bis-glycine chelate is an iron compound that ...
Mating effects on female reproductive organs: the paradigm of estrogen signaling pathways in the oviduct
(Nova Science Publishers, 2013)
Mating induces several physiological changes in the female reproductive tract
independently of oocyte fertilization, which are potentially required for a
successful pregnancy. These effects include modifications in the ...
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes
(Nature Publishing Group, 2004-02-04)
1 We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs),
including 4-I¼2C-I, 4-Br¼2C-B, and 4-CH3¼2C-D analogs, are partial agonists at 5-HT2C
receptors, and show low or even negligible ...