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Narcolepsy, Infections, and Autoimmunity
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin-producing neurons in the lateral hypothalamus. There is evidence suggesting an autoimmune-mediated ...
THU0338 Does Age at Onset of SjöGren’s Syndrome Influence the Course and Severity of the Disease?
Background Age at onset of disease (AOD) refers to the time period at which a patient experiences the first symptom(s). AOD varies among autoimmune diseases (ADs) and has been related to prognosis in some of them. Genetic, ...
Critical role of HLA-DR?* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development
A vaccine candidate component must fit perfectly into the antigen presenting HLA-DR?* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), ...
Are autoimmune diseases predictable?
Autoimmune diseases are complex diseases resulting of the interaction between both genetics and environmental factors over time. Different phases in the development of autoimmune diseases are characterized by the detection ...
Monogenic polyautoimmunity in primary immunodeficiency diseases
Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, ...
Infarto pulmonar cavitado
48-year-old patient with a one-month picture of chest pain, cough with purulent expectoration and fever. Referred for management with diagnosis of lung abscess. Contrast-enhanced chest CT demonstrated cavitated lung mass ...
Electrostatic potential as a tool to understand interactions between malaria vaccine candidate peptides and MHC II molecules
One of the most important problems in vaccine development consists in understanding receptor-ligand interactions between Class II Major Histocompatibility Complex molecules (MHC II) and antigenic peptides involved in ...
Definition of acquired toxoplasmosis infection: When is it congenital or acquired?
We read with great interest the article by Álvarez et al. recently published in the Spanish Ophthalmological Society on the clinical characteristics of ocular toxoplasmosis in an immigrant population in Barcelona, Spain.1 ...
Atomic fidelity of subunit-based chemically-synthesized antimalarial vaccine components
The tri-dimensional (3D) structure determined by NMR of functionally relevant High Activity Binding Peptides (HABPs) of chemically-synthesized malarial proteins, involved in invasion to target cells, is practically identical, ...
The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development
Analysis of our Plasmodium falciparum malaria parasite peptides’ 1H-NMR database in the search for H-bonds and ?-interactions led us to correlate their presence or absence with a peptide's particular immunological behavior. ...