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Evaluation of the novel antichagasic activity of [1,2,3]triazolo[1,5-a]pyridine derivatives
(Bentham Science Publishers B.V., 2017)
© 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
(BioMed Central Ltd., 2014)
© 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
PGC-1α-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells
(Hindawi Publishing Corporation, 2016)
Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. ...
Diversity, frequency and antifungal resistance of Candida species in patients with type 2 diabetes mellitus
(Taylor and Francis Ltd, 2018)
Objective: To determine number, species of Candida and Candida resistance to antifungal therapy according to the metabolic control state and the associated salivary changes in patients with type 2 diabetes mellitus ...
Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish
(2005)
This paper describes for the first time a massive intoxication episode due to consumption of shellfish contaminated with 7-O-acyl-derivative dinophysistoxin-1, named Dinophysistoxin-3 (DTX-3). 7-O-acyl-derivative ...
Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model
(Elsevier Ltd, 2017)
Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the ...
Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1
(Wiley-Liss, 2014)
In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties
of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
(ELSEVIER SCIENCE INC, 2010-02-15)
We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
(ELSEVIER SCIENCE BV, 2010-03)
Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
(ELSEVIER SCIENCE BV, 2011-01)
Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...