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A cyclic peptide derived from α-fetoprotein inhibits the proliferative effects of the epidermal growth factor and estradiol in MCF7 cells
(2008)
A cyclic peptide derived from the active domain of α-fetoprotein (AFP) significantly inhibited the proliferation of MCF7 cells stimulated with the epidermal growth factor (EGF) or estradiol (E 2). The action of these three ...
The polyanions heparin and suramin impede binding of free adenine to a DNA glycosylase from C. pseudotuberculosis
(2019-03-15)
Currently no effective treatment is available to combat infections caused by Corynebacterium pseudotuberculosis in livestock. Survival of this Gram-positive bacterium in rapidly-growing pathogens in hostile environments ...
Heparin affects the interaction of kininogen on endothelial cells
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2011)
In the plasma kallikrein-kinin system, it has been shown that when plasma prekallikrein (PM) and high molecular weight kininogen (HK) assemble on endothelial cells, plasma kallikrein (huPK) becomes available to cleave HK, ...
CrataBL, a lectin and Factor Xa inhibitor, plays a role in blood coagulation and impairs thrombus formation
(Walter De Gruyter Gmbh, 2014-09-01)
Arterial thrombosis is an important complication of diabetes and cancer, being an important target for therapeutic intervention. Crataeva tapia bark lectin (CrataBL) has been previously shown to have hypoglycemiant effect ...
DNA and heparin chaperone the refolding of purified recombinant replication protein A subunit 1 from Leishmania amazonensis
(Elsevier Science BvAmsterdamHolanda, 2009)
Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011)
The molecular mechanism of factor Xa (FXa) inhibition by Alboserpin, the major salivary gland anticoagulant from the mosquito and yellow fever vector Aedes albopictus, has been characterized. cDNA of Alboserpin predicts a ...
Proteinase activity regulation by glycosaminoglycans
(Associação Brasileira de Divulgação Científica, 2002-02-01)
There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and ...
Perfil protéico do sêmen e fertilidade de touros da raça Gir
(Universidade Federal de Minas GeraisUFMG, 2007-12-19)
It was studied semen total protein and heparin binding protein profile of 15 Gyr bulls and itsassociation with andrological characteristics and in vitro fertility potential. It was verified yetassociations among andrological, ...
Tissue Damage and Inflammation Induced by Snake Venoms
(2014-03-27)
Some characteristics of the local tissue damage and inflammatory reactions
induced by snake venoms were analyzed in a mouse model. Tissue damage was
studied by intravital, light, and electron microscopic techniques, and ...