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CrataBL, a lectin and Factor Xa inhibitor, plays a role in blood coagulation and impairs thrombus formation
(Walter de Gruyter Gmbh, 2014-09-01)
Arterial thrombosis is an important complication of diabetes and cancer, being an important target for therapeutic intervention. Crataeva tapia bark lectin (CrataBL) has been previously shown to have hypoglycemiant effect ...
CrataBL, a lectin and Factor Xa inhibitor, plays a role in blood coagulation and impairs thrombus formation
(Walter De Gruyter Gmbh, 2015)
PLASMA KALLIKREIN and THROMBIN ARE CLEARED THROUGH UNRELATED HEPATIC PATHWAYS
(Rapid Science Publishers, 1993-08-01)
Plasma kallikrein (PK) and thrombin (TH), serine proteinases formed from inactive precursors, participate in important body defence mechanisms. the isolated hepatocyte recognizes TH, and the liver clears PK by calcium-independent ...
Inhibitory Peptides of the Sulfotransferase Domain of the Heparan Sulfate Enzyme, N-Deacetylase-N-sulfotransferase-1
(Amer Soc Biochemistry Molecular Biology Inc, 2011-02-18)
N-Deacetylase-N-sulfotransferase 1 (Ndst1) catalyzes the initial modification of heparan sulfate and heparin during their biosynthesis by removal of acetyl groups from subsets of N-acetylglucosamine units and subsequent ...
Methods for obtaining the enriched fraction of ram seminal vesicle proteins (RSVP14)
(Brazilian Journal of Animal Science, 2023)
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin
(1993-12-01)
Both human and bovine prothrombin fragment 2 (the second kringle) have been cocrystallized separately with human PPACK (D-Phe-Pro-Arg)-thrombin, and the structures of these noncovalent complexes have been determined and ...
Biological and structural characterization of a new PLA(2) from the Crotalus durissus collilineatus venom
(Springer, 2005-02-01)
In the present article we report on the biological characterization and amino acid sequence of a new basic Phospholipases A(2) (PLA(2)) isolated from the Crotalus durissus collilineatus venom (Cdcolli F6), which showed the ...
Interfacial surface charge and free accessibility to the PLA(2)-active site-like region are essential requirements for the activity of Lys49 PLA(2) homologues
(Elsevier B.V., 2007-03-01)
Lys49 phospholipase A(2) homologues are highly myotoxic and cause extensive tissue damage but do not display hydrolytic activity towards natural phospholipids. The binding of heparin, heparin derivatives and polyanionic ...
Haemagglutination induced by Bordetella pertussis filamentous haemagglutinin adhesin (FHA) is inhibited by antibodies produced against FHA(430-873) fragment expressed in Lactobacillus casei
(Springer, 2006-12-01)
Filamentous haemagglutinin adhesin (FHA) is an important virulence factor from Bordetella pertussis related to the adhesion and spread of the bacteria through the respiratory tract. Three distinct domains have been ...
Involvement of host cell heparan sulfate proteoglycan in Trypanosoma cruzi amastigote attachment and invasion
(Cambridge Univ Press, 2011-04-01)
Cell surface glycosaminoglycans (GAGs) play an important role in the attachment and invasion process of a variety of intracellular pathogens. We have previously demonstrated that heparan sulfate proteoglycans (HSPG) mediate ...